EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle

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Cardoso, T. F. ; Bruscadin, J. J. ; Afonso, J. ; Petrini, J. ; Andrade, B. G. N. ; de Oliveira, P. S. N. ; Malheiros, J. M. ; Rocha, M. I. P. ; Zerlotini, A. ; Ferraz, J. B. S. ; Mourao, G. B. ; Coutinho, L. L. ; Regitano, L. C. A.

• Tipo de documento: Artigo Científico
• Fonte: Mammalian Genome; v. 33, n. 4, p. 10-pg., 2022-07-11.

Resumo

Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes' expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (beta = 3.02; P-value = 3.51E-03) and the residual feed intake trait (beta = - 3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, co-expression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle. (AU)

• Processo FAPESP: 18/11953-2 - Variações em regiões regulatórias associadas a características de produção e qualidade de carne na raça Nelore
• Beneficiário: Tainã Figueiredo Cardoso
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 12/23638-8 - Bases moleculares da qualidade da carne em bovinos da raça Nelore
• Beneficiário: Luciana Correia de Almeida Regitano
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 19/04089-2 - O Hologenoma de Nelore: implicações na qualidade de carne e em eficiência alimentar
• Beneficiário: Luciana Correia de Almeida Regitano
• Modalidade de apoio: Auxílio à Pesquisa - Programa eScience e Data Science - Temático