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| Autor(es): Mostrar menos - |
Noronha, Natalia Yumi
;
Rodrigues, Guilherme da Silva
;
Yonehara Noma, Isabella Harumi
;
Cunha Brandao, Camila Fernanda
;
Rodrigues, Karine Pereira
;
Bruno, Alexandre Colello
;
Sae-Lee, Chanachai
;
Watanabe, Ligia Moriguchi
;
de Souza Pinhel, Marcela Augusta
;
Schineider, Isabelle Mello
;
de Almeida, Mariana Luciano
;
Junior, Fernando Barbosa
;
Morais, Deborah Araujo
;
de Sousa Junior, Wellington Tavares
;
Plosch, Torsten
;
Bueno Junior, Carlos Roberto
;
Nonino, Carla Barbosa
Número total de Autores: 17
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| Tipo de documento: | Artigo Científico |
| Fonte: | FRONTIERS IN ENDOCRINOLOGY; v. 13, p. 15-pg., 2022-08-15. |
| Resumo | |
BackgroundPre-diabetes precedes Diabetes Mellitus (DM) disease and is a critical period for hyperglycemia treatment, especially for menopausal women, considering all metabolic alterations due to hormonal changes. Recently, the literature has demonstrated the role of physical exercise in epigenetic reprogramming to modulate the gene expression patterns of metabolic conditions, such as hyperglycemia, and prevent DM development. In the present study, we hypothesized that physical exercise training could modify the epigenetic patterns of women with poor glycemic control. Methods48 post-menopause women aged 60.3 +/- 4.5 years were divided according to their fasting blood glucose levels into two groups: Prediabetes Group, PG (n=24), and Normal Glucose Group, NGG (n=24). All participants performed 14 weeks of physical exercise three times a week. The Infinium Methylation EPIC BeadChip measured the participants' Different Methylated Regions (DMRs). ResultsBefore the intervention, the PG group had 12 DMRs compared to NGG. After the intervention, five DMRs remained different. Interestingly, when comparing the PG group before and after training, 118 DMRs were found. The enrichment analysis revealed that the genes were related to different biological functions such as energy metabolism, cell differentiation, and tumor suppression. ConclusionPhysical exercise is a relevant alternative in treating hyperglycemia and preventing DM in post-menopause women with poor glycemic control. (AU) | |
| Processo FAPESP: | 20/08687-9 - Deficiência de selênio: identificação de um perfil de risco considerando fatores genéticos, clínicos e ambientais de pacientes com Obesidade no pré e pós-operatório da cirurgia bariátrica |
| Beneficiário: | Lígia Moriguchi Watanabe |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/21361-2 - Screening global de fatores genéticos e epigenéticos associados com magnitude de resposta a diferentes treinamentos físicos em mulheres de 50 a 70 anos |
| Beneficiário: | Carlos Roberto Bueno Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua |
| Beneficiário: | Fernando Barbosa Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 14/16740-6 - Expressão de genes relacionados ao gasto energético e metabolismo de lipídios de indivíduos com obesidade grau III antes e após intervenções para perda de peso |
| Beneficiário: | Natália Yumi Noronha |
| Modalidade de apoio: | Bolsas no Brasil - Programa Capacitação - Treinamento Técnico |