| Texto completo | |
| Autor(es): |
Silva, Tamiris R. C.
;
Souza, Vinicius V.
;
Raminelli, Cristiano
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRYSELECT; v. 7, n. 33, p. 4-pg., 2022-09-06. |
| Resumo | |
Herein, we report our investigations on the reaction of a variety of substituted oxazoles with o-(trimethylsilyl)aryl triflates promoted by potassium fluoride and 18-crown-6-ether. Several functionalized isoquinoline compounds were obtained in moderate to good yields when the transformation was carried out at room temperature, followed by acidic workup, presumably via a [4+2] cycloaddition-ring-opening reaction pathway. Alternatively, bicyclic ethers were produced in reasonable yields when performing the transformation at 60 degrees C via a sequence of [4+2] cycloaddition, retro-Diels-Alder, and [4+2] cycloaddition reactions. (AU) | |
| Processo FAPESP: | 20/12530-8 - 2-(Trimetilsilil)aril trifluorometanossulfonatos como precursores de arinos visando à preparação de compostos (hetero)aromáticos funcionalizados e sínteses de produtos naturais bioativos |
| Beneficiário: | Cristiano Raminelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |