Diabetes and bone

Autor(es)

de Araujo, Iona Mizumukai ; Mascarenhas Moreira, Mariana Lima ; Albuquerque de Paula, Francisco Jose

• Tipo de documento: Artigo Científico
• Fonte: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 66, n. 5, p. 9-pg., 2022-09-01.

Resumo

Globally, one in 11 adults has diabetes mellitus of which 90% have type 2 diabetes. The numbers for osteoporosis are no less staggering: 1 in 3 women has a fracture after menopause, and the same is true for 1 in 5 men after the age of 50 years. Aging is associated with several physiological changes that cause insulin resistance and impaired insulin secretion, which in turn lead to hyperglycemia. The negative balance between bone resorption and formation is a natural process that appears after the fourth decade of life and lasts for the following decades, eroding the bone structure and increasing the risk of fractures. Not incidentally, it has been acknowledged that diabetes mellitus, regardless of whether type 1 or 2, is associated with an increased risk of fracture. The nuances that differentiate bone damage in the two main forms of diabetes are part of the intrinsic heterogeneity of diabetes, which is enhanced when associated with a condition as complex as osteoporosis. This narrative review addresses the main parameters related to the increased risk of fractures in individuals with diabetes, and the mutual factors affecting the treatment of diabetes mellitus and osteoporosis. Arch Endocrinol Metab. 2022;66(5):633-41 (AU)

• Processo FAPESP: 18/18071-5 - Homeostase hidroeletrolítica e energética: do metabolismo celular aos sistemas endócrinos em diferentes fases do desenvolvimento
• Beneficiário: Lucila Leico Kagohara Elias
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/03152-2 - Interação entre tecido adiposo, muscular e ósseo na anorexia nervosa
• Beneficiário: Iana Mizumukai de Araujo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado