Controlled release of vitamin D-3 using a nanocellulose-based membrane

Autor(es)

Colturato, Pedro L. ; Goveia, Danielle

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 12, n. 1, p. 11-pg., 2022-07-20.

Resumo

Epidemiological studies show that a significant fraction of the global population presents low levels of vitamin D-3. In order to address this problem, one way to administer the vitamin is to incorporate it in novel drug delivery systems, such as transdermal devices. A possible substance for this purpose is cellulose, which has a long history of use in the health area. However, the application of nanostructured cellulose membranes, as local drug delivery systems, remains a challenge. To develop a crystalline nanocellulose membrane as a new tool for the release of vitamin D-3. A new nanostructured membrane containing nanocellulose extracted from cotton linter and vitamin D-3 was produced using the "casting" technique. The membrane was characterized using high-resolution scanning electron microscopy (FEG-SEM) and Fourier transform infrared spectroscopy (FT-IR). The kinetics of vitamin release was quantified using molecular spectroscopy (UV-Vis). The FT-IR spectra showed the presence of all the active components in the membrane sample, without structural alterations or the formation of new bonds. The FEG-SEM images showed the presence of vitamin crystals on the surface and in the interior of the membrane. The release of vitamin D-3 occurred in a sustained manner, obtaining 3029 IU mL(-1) of vitamin D-3 in 60 min. The findings demonstrated that the membrane could be used for the sustained release of vitamin D-3. This new biomaterial has potential as a new model for vitamin supplementation in individuals with vitamin D-3 deficiency. (AU)

• Processo FAPESP: 19/24684-2 - Funcionalização de nanocelulose para remediação de sistemas aquáticos contaminados por metais tóxicos
• Beneficiário: Danielle Goveia
• Modalidade de apoio: Auxílio à Pesquisa - Regular