Photocurable Nitric Oxide-Releasing Copolyester for the 3D Printing of Bioresorbable Vascular Stents

Autor(es)

de Oliveira, Matheus F. ; da Silva, Laura C. E. ; Catori, Daniele M. ; Lorevice, Marcos, V ; Galvao, Karen E. A. ; Millas, Ana L. G. ; de Oliveira, Marcelo G.

• Tipo de documento: Artigo Científico
• Fonte: Macromolecular Bioscience; v. N/A, p. 14-pg., 2022-12-25.

Resumo

The design of bioresorbable vascular stents (BVS) capable of releasing nitric oxide (NO) at the implant site may enable BVS to mimic the antiplatelet, antiproliferative, and pro-endothelial actions of NO, overcoming complications of BVS such as late thrombosis and restenosis. In this study, the fabrication of BVS composed of methacrylated poly(dodecanediol citrate-co-dodecanediol S-nitroso-mercaptosuccinate) (mP(DC-co-DMSNO)), a novel elastomeric, bioabsorbable, and photocurable copolyester, containing covalently bound S-nitrosothiol groups in the carbon backbone of the polymer, is reported. The mP(DC-co-DMSNO) stents are manufactured via photoinduced 3D printing and allow deployment via a self-expansion process from a balloon catheter. After deployment, hydration of the stents triggers the release of NO, which is maintained during the slow hydrolysis of the polymer. Real-time NO release measurements show that by varying the copolyester composition and the strut geometry of the mP(DC-co-DMSNO) stents, it is possible to modulate their NO release rate in the range of 30-52 pmol min(-1) cm(-2). Preliminary biological assays in cell culture show that endothelial cells adhere to the surface of the stents and that NO release favors their endothelization. Thus, mP(DC-co-DMSNO) may emerge as a new platform for the fabrication of advanced BVS. (AU)

• Processo FAPESP: 18/02520-5 - Stents bioabsorvíveis de poliésteres polinitrosados doadores de óxido nítrico
• Beneficiário: Matheus Fernandes de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 16/02414-5 - Biomateriais absorvíveis e tópicos para a liberação localizada de óxido nítrico
• Beneficiário: Marcelo Ganzarolli de Oliveira
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/14142-5 - Hidrogéis híbridos para liberação localizada e prolongada de óxido nítrico
• Beneficiário: Laura Caetano Escobar da Silva
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 21/00491-0 - Hidrogéis termosensíveis de Pluronic F127 funcionalizados com grupos terminais liberadores de óxido nítrico
• Beneficiário: Marcos Vinicius Lorevice
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado