| Texto completo | |
| Autor(es): Mostrar menos - |
Boeing, Thaise
;
Monteiro Magalhaes de Oliveira, Beatriz
;
Aldana-Mejia, Jennyfer Andrea
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Vidal Ccana-Ccapatinta, Gari
;
Venzon, Larissa
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Judah Cury, Benhur
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Santos Franca, Tauani Caroline
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de Souza, Priscila
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Roman Junior, Walter Antonio
;
Mota da Silva, Luisa
;
Kenupp Bastos, Jairo
Número total de Autores: 11
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| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMISTRY & BIODIVERSITY; v. 20, n. 1, p. 14-pg., 2022-12-13. |
| Resumo | |
Propolis has been used for the treatment of gastric disturbances in folk medicine, nevertheless, the gastric healing effects of Brazilian red propolis have not been unveiled. This study aimed to assess the gastric healing effect of the hydroalcoholic extract of red propolis (HERP) in the acetic acid-induced ulcer model. Rats under acetic acid-induced-ulcer were treated with HERP (100 mg/kg, p.o.) twice a day for seven days. Histological changes, oxidative stress, and inflammatory parameters were analyzed in the gastric tissue. Moreover, the gastric wall thickness was measured by ultrasound. The in vitro cytotoxicity of HERP and cellular migration of fibroblasts were evaluated. The treatment with HERP promoted gastric healing, reducing gastric wall thickness, macroscopic lesion area, and histopathological damages compared to the vehicle. Moreover, HERP reduced oxidative stress and inflammation in the gastric tissue but did not change mucin or collagen levels. HERP did not show signs of toxicity either in vivo or in vitro. HERP displayed a healing effect in vivo by reducing oxidative stress and inflammation. These data contribute to validating the popular use of this product in the treatment of gastric disorders and advance scientific knowledge in the search for new drugs for the management of gastric ulcers. (AU) | |
| Processo FAPESP: | 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |