Clinical treatment of intra-epithelia cervical neoplasia with photodynamic therapy

Autor(es)

Vendette, Antonio Carlos Figueiredo ; Piva, Henrique Luis ; Muehlmann, Luis Alexandre ; de Souza, Delfrank Ananias ; Tedesco, Antonio Claudio ; Azevedo, Ricardo Bentes

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF HYPERTHERMIA; v. 37, n. 3, p. 9-pg., 2020-12-15.

Resumo

Objectives: This clinical study was developed to primarily evaluate the Complete Cytopathological Response Rate of Cervical Intraepithelial Neoplasms to PDT using chitosan nanocapsules containing Chlorocyan-aluminum phthalocyanine as a photoactive agent. Analyses of the Free Recurrence Interval, toxicity profile (immediate and late), and complications (immediate and late), were secondarily analyzed. Methods: This study was previously approved by the National Council of Ethics in Research of Brazil (CONEP), on May 28, 2014, under case number 19182113.4.0000.5009. On the surface of the cervix of each selected patient was applied one mL of the formulated gel, and after 30 min, the light was applied. Reports or the identification of adverse effects and/or complications were observed in follow-up visits, in addition to the collection of cervical oncotic cytology. Results: Out of the total group, 11 (91.7%) primarily treated patients evolved with negative cervical oncotic cytology as soon as in the first evaluation following treatment, and one did not achieve any therapeutic benefit, even after reapplication. Two patients with initially positive response presented cytological recurrence determined by histopathology. A new round of PDT was developed, and both evolved with cytological remission three weeks later, remaining negative until the last follow-up. No important side effects were observed in all the patients. Conclusions: Our trial demonstrates that treatment of CIN 1 and 2 lesions using our PDT formulation is feasible and safe. Large randomized clinical trials are required to establish efficacy. (AU)

• Processo FAPESP: 13/50181-1 - Utilização de nanocarreadores contendo fármacos fotossensibilizantes e outros ativos aplicados à terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Antonio Claudio Tedesco
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 17/16356-0 - Utilização de nanocarreadores contendo fármacos fotossensibilizadores e outros ativos aplicados a terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Henrique Luis Piva
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico