| Texto completo | |
| Autor(es): Mostrar menos - |
Kappes, Lucy
;
Amer, Ruba L.
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Sommerlatte, Sabine
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Bashir, Ghada
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Plattfaut, Corinna
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Gieseler, Frank
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Gemoll, Timo
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Busch, Hauke
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Altahrawi, Abeer
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Al-Sbiei, Ashraf
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Haneefa, Shoja M.
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Arafat, Kholoud
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Schimke, Lena F.
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El Khawanky, Nadia
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Schulze-Forster, Kai
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Heidecke, Harald
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Kerstein-Staehle, Anja
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Marschner, Gabriele
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Pitann, Silke
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Ochs, Hans D.
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Mueller, Antje
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Attoub, Samir
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Fernandez-Cabezudo, Maria J.
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Riemekasten, Gabriela
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al-Ramadi, Basel K.
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Cabral-Marques, Otavio
Número total de Autores: 26
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| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENTIFIC REPORTS; v. 10, n. 1, p. 15-pg., 2020-09-28. |
| Resumo | |
Several studies reported a central role of the endothelin type A receptor (ETAR) in tumor progression leading to the formation of metastasis. Here, we investigated the in vitro and in vivo anti-tumor effects of the FDA-approved ETAR antagonist, Ambrisentan, which is currently used to treat patients with pulmonary arterial hypertension. In vitro, Ambrisentan inhibited both spontaneous and induced migration/invasion capacity of different tumor cells (COLO-357 metastatic pancreatic adenocarcinoma, OvCar3 ovarian carcinoma, MDA-MB-231 breast adenocarcinoma, and HL-60 promyelocytic leukemia). Whole transcriptome analysis using RNAseq indicated Ambrisentan's inhibitory effects on the whole transcriptome of resting and PAR2-activated COLO-357 cells, which tended to normalize to an unstimulated profile. Finally, in a pre-clinical murine model of metastatic breast cancer, treatment with Ambrisentan was effective in decreasing metastasis into the lungs and liver. Importantly, this was associated with a significant enhancement in animal survival. Taken together, our work suggests a new therapeutic application for Ambrisentan in the treatment of cancer metastasis. (AU) | |
| Processo FAPESP: | 20/01688-0 - Análise sistêmica e integrativa da resposta imune às infecções virais por Zika e Dengue |
| Beneficiário: | Otávio Cabral Marques |
| Modalidade de apoio: | Bolsas no Brasil - Jovens Pesquisadores |