| Texto completo | |
| Autor(es): |
Rosa, Leticia B.
;
Aires, Rochanna L.
;
Oliveira, Laiane S.
;
Fontes, Josielle V.
;
Miguel, Danilo C.
;
Abbehausen, Camilla
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | CHEMMEDCHEM; v. 16, n. 11, p. 15-pg., 2021-03-22. |
| Resumo | |
Leishmaniasis is one of the most neglected diseases worldwide and is considered a serious public health issue. The current therapeutic options have several disadvantages that make the search for new therapeutics urgent. Gold compounds are emerging as promising candidates based on encouraging in vitro and limited in vivo results for several Au-I and Au-III complexes. The antiparasitic mechanisms of these molecules remain only partially understood. However, a few studies have proposed the trypanothione redox system as a target, similar to the mammalian thioredoxin system, pointed out as the main target for several gold compounds with significant antitumor activity. In this review, we present the current status of the investigation and design of gold compounds directed at treating leishmaniasis. In addition, we explore potential targets in Leishmania parasites beyond the trypanothione system, taking into account previous studies and structure modulation performed for gold-based compounds. (AU) | |
| Processo FAPESP: | 14/21129-4 - O papel das proteínas ligantes de ácidos graxos na infecção de macrófagos por Leishmania: um alvo potencial para novas drogas contra leishmaniose |
| Beneficiário: | Danilo Ciccone Miguel |
| Modalidade de apoio: | Auxílio à Pesquisa - Jovens Pesquisadores |
| Processo FAPESP: | 19/16904-2 - Metalofármacos direcionados a alvos específicos para o tratamento de leishmaniose |
| Beneficiário: | Camilla Abbehausen |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 18/21120-8 - Metalofármacos inibidores seletivos de zinc fingers para o tratamento de doenças parasitárias |
| Beneficiário: | Camilla Abbehausen |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |