Conceptus-modulated innate immune function during early pregnancy in ruminants: a review

Autor(es)

Rocha, Cecilia Constantino ; Da Silveira, Juliano Coelho ; Forde, Niamh ; Binelli, Mario ; Pugliesi, Guilherme

• Tipo de documento: Artigo Científico
• Fonte: ANIMAL REPRODUCTION; v. 18, n. 1, p. 16-pg., 2021-01-01.

Resumo

This review focuses on the innate immune events modulated by conceptus signaling during early pregnancy in ruminants. Interferon-tau (IFN-tau) plays a role in the recognition of pregnancy in ruminants, which involves more than the inhibition of luteolytic pulses of PGF2 alpha to maintain corpus luteum function. For successful pregnancy establishment, the allogenic conceptus needs to prevent rejection by the female. Therefore, IFN-tau exerts paracrine and endocrine actions to regulate the innate immune system and prevent conceptus rejection. Additionally, other immune regulators work in parallel with IFN-tau, such as the pattern recognition receptors (PRR). These receptors are activated during viral and bacterial infections and in early pregnancy, but it remains unknown whether PPR expression and function are controlled by IFN-tau. Therefore, this review focuses on the main components of the innate immune response that are involved with early pregnancy and their importance to avoid conceptus rejection. (AU)

• Processo FAPESP: 19/02995-6 - Estudo das vias enriquecidas em células imunes durante o início da gestação e novos marcadores de gestação no sangue de fêmeas bovinas
• Beneficiário: Cecilia Constantino Rocha
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Mestrado
• Processo FAPESP: 17/13994-5 - Estudo do perfil transcriptômico em células imunes do sangue periférico no início da gestação em novilhas de corte
• Beneficiário: Cecilia Constantino Rocha
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 15/10606-9 - Inovações no diagnóstico precoce da gestação em bovinos
• Beneficiário: Guilherme Pugliesi
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores