A modular and reusable model of epithelial transport in the proximal convoluted tubule

Autor(es)

Noroozbabaee, Leyla ; Blanco, Pablo J. ; Safaei, Soroush ; Nickerson, David P.

• Tipo de documento: Artigo Científico
• Fonte: PLoS One; v. 17, n. 11, p. 30-pg., 2022-11-10.

Resumo

We review a collection of published renal epithelial transport models, from which we build a consistent and reusable mathematical model able to reproduce many observations and predictions from the literature. The flexible modular model we present here can be adapted to specific configurations of epithelial transport, and in this work we focus on transport in the proximal convoluted tubule of the renal nephron. Our mathematical model of the epithelial proximal convoluted tubule describes the cellular and subcellular mechanisms of the transporters, intracellular buffering, solute fluxes, and other processes. We provide free and open access to the Python implementation to ensure our multiscale proximal tubule model is accessible; enabling the reader to explore the model through setting their own simulations, reproducibility tests, and sensitivity analyses. (AU)

• Processo FAPESP: 14/50889-7 - INCT 2014: em Medicina Assistida por Computação Científica (INCT-MACC)
• Beneficiário: José Eduardo Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/14221-2 - Geometria das bifurcações coronárias: um estudo exploratório das leis matemáticas para estimar as dimensões vasculares em bifurcações coronárias
• Beneficiário: Gabriela Hidalgo Vargas dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica