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Immunomodulation by testosterone and corticosterone in toads: Experimental evidences from transdermal application

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Autor(es):
Madelaire, Carla Bonetti ; Cassettari, Bruna de Oliveira ; Gomes, Fernando Ribeiro
Número total de Autores: 3
Tipo de documento: Artigo Científico
Fonte: General and Comparative Endocrinology; v. 273, p. 9-pg., 2019-03-01.
Resumo

Androgens and glucocorticoids play important roles in vertebrate's reproduction and display complex immunomodulatory functions that may affect survival. In anurans, testosterone and corticosterone are correlated to sexual behavior, reproduction, and immune function. Male toads (Rhinella jimi) were treated with acute doses of testosterone (T) and corticosterone (CORT) and immune variables (plasma bacterial killing ability [BKA], swelling after phytohemagglutinin [PHA] injection and the time point of maximum PHA swelling response) were measured. Transdermal T and CORT application increased androgen (T-DHT) and CORT plasma levels after 1 h of treatment, respectively, without a dose-specific effect. Transdermal T treatment did not affect BKA or PHA swelling response. Individuals treated with transdermal CORT showed an earlier maximum PHA swelling response and a tendency of lower BKA 15 h after treatment. Our results indicated that an acute experimental increase of CORT plasma levels diminished time for inflammatory resolution and suppressed non-cellular innate response. (AU)

Processo FAPESP: 13/00900-1 - Estudo comparativo das relações entre imunocompetência e níveis plasmáticos de esteróides inter-renais e gonadais em sapos
Beneficiário:Fernando Ribeiro Gomes
Modalidade de apoio: Auxílio à Pesquisa - Regular
Processo FAPESP: 12/24206-4 - Relação sazonal entre reprodução, energética e imunocompetência em sapos (Rhinella jimi) da Caatinga
Beneficiário:Carla Bonetti Madelaire
Modalidade de apoio: Bolsas no Brasil - Doutorado