| Texto completo | |
| Autor(es): |
Rodrigues, Caroline Zani
;
Correia, Thais Carlos
;
Ribeiro Neves, Paulo Augusto
;
Malta, Maira Barreto
;
Cardoso, Marly Augusto
;
Lourenco, Barbara Hatzlhoffer
;
MINA-Brazil Study Grp
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | European Journal of Clinical Nutrition; v. 76, n. 9, p. 8-pg., 2022-02-21. |
| Resumo | |
Objectives To determine predictors of 25-hydroxyvitamin D-3 (25(OH)D-3) concentrations (25(th), 50(th), and 75(th) percentiles) in the third trimester of pregnancy. Subjects/methods Data on sociodemographic, obstetric, lifestyle and pregnancy characteristics, including serum 25(OH)D-3 and retinol, were collected among 448 pregnant women who participated in the Maternal and Child Health and Nutrition in Acre, Brazil (MINA-Brazil Study) in Cruzeiro do Sul, Brazilian Amazon (latitude 7 degrees S). Simultaneous-quantile regression was fitted to prospectively assess predictors at the 25(th), 50(th) and 75(th) percentiles of 25(OH)D-3 concentrations. Results In the third trimester, 25(OH)D-3 <50 nmol/L was observed in 26% of pregnant women. Exposure to the Amazonian dry season during follow-up and vitamin D status >= 75 nmol/L in the second trimester of pregnancy were positively associated with 25(OH)D-3 concentrations in the third trimester. Pregnant women who were the main providers of family income presented lower 25(OH)D-3 concentrations (50(th) and 75(th) percentiles: -15 nmol/L, 95%CI -24; -3, p = 0.02, and -22 nmol/L, 95%CI -36; -7, p = 0.004, respectively), as well as those with sustained vitamin A insufficiency (25(th) and 50(th) percentiles: -27 nmol/L, 95%CI -40; -15, p < 0.001, and -17 nmol/L, 95%CI -33; -1, p = 0.04, respectively). Sun protection practices had a smaller negative impact on 25(OH)D-3, restricted to participants whose concentrations were at the 25(th) percentile of the distribution. Conclusions Seasonality and vitamin A status were important predictors of 25(OH)D-3 concentrations in the third trimester. Adequate exposure to sunlight and dietary sources of vitamin A within safe intake levels may help ensuring a good nutritional status of vitamin D during pregnancy. (AU) | |
| Processo FAPESP: | 16/00270-6 - Estudo MINA - Materno-Infantil no Acre: coorte de nascimentos da Amazônia Ocidental Brasileira |
| Beneficiário: | Marly Augusto Cardoso |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |