Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease

Autor(es)

Villegas, Cecilia ; Perez, Rebeca ; Petiz, Lyvia Lintzmaier ; Glaser, Talita ; Ulrich, Henning ; Paz, Cristian

• Tipo de documento: Artigo Científico
• Fonte: IUBMB Life; v. 74, n. 8, p. 17-pg., 2022-04-05.

Resumo

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by gradual deterioration of cognitive function, memory, and inability to perform daily, social, or occupational activities. Its etiology is associated with the accumulation of beta-amyloid peptides, phosphorylated tau protein, and neuroinflammatory and oxidative processes in the brain. Currently, there is no successful pharmacological treatment for AD. The few approved drugs are mainly aimed at treating the symptoms; however, due to the increasing discovery of etiopathological factors, there are great efforts to find new multifunctional molecules to slow down the course of this neurodegenerative disease. The commercial Ginkgo biloba formulation EGb 761 (R) and Huperzine A, an alkaloid present in the plant Huperzia serrata, have shown in clinical trials to possess cholinergic and neuroprotective activities, including improvement in cognition, activities of daily living, and neuropsychiatric symptoms in AD patients. The purpose of this review is to expose the positive results of intervention with EGb 761 (R) and Huperzine in patients with mild to moderate AD in the last 10 years, highlighting the pharmacological functions that justify their use in AD therapy. (AU)

• Processo FAPESP: 18/08426-0 - Alcalóides indólicos, subprodutos do processamento de Maqui (Aristotelia chilensis) como aditivos alimentares no tratamento da Doença de Alzheimer
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 18/07366-4 - Receptores de purinas e cininas como alvos de estudo e intervenção terapêutica em doenças neurológicas
• Beneficiário: Alexander Henning Ulrich
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 21/00060-0 - Papel da modulação do receptor P2Y14 na resposta neuroinflamatória hipocampal em modelos in vitro e in vivo de Doença de Alzheimer
• Beneficiário: Lyvia Lintzmaier Petiz
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado