| Texto completo | |
| Autor(es): |
Katayama, Pedro L.
;
Leirao, Isabela P.
;
Kanashiro, Alexandre
;
Luiz, Joao P. M.
;
Cunha, Fernando Q.
;
Navegantes, Luiz C. C.
;
V. Menani, Jose
;
Zoccal, Daniel B.
;
Colombari, Debora S. A.
;
Colombari, Eduardo
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BRAIN BEHAVIOR AND IMMUNITY; v. 102, p. 17-pg., 2022-03-25. |
| Resumo | |
Recent evidence has suggested that the carotid bodies might act as immunological sensors, detecting pro-inflammatory mediators and signalling to the central nervous system, which, in turn, orchestrates autonomic responses. Here, we confirmed that the TNF-alpha receptor type I is expressed in the carotid bodies of rats. The systemic administration of TNF-alpha increased carotid body afferent discharge and activated glutamatergic neurons in the nucleus tractus solitarius (NTS) that project to the rostral ventrolateral medulla (RVLM), where many pre-sympathetic neurons reside. The activation of these neurons was accompanied by an increase in splanchnic sympathetic nerve activity. Carotid body ablation blunted the TNF-alpha-induced activation of RVLM-projecting NTS neurons and the increase in splanchnic sympathetic nerve activity. Finally, plasma and spleen levels of cytokines after TNF-alpha administration were higher in rats subjected to either carotid body ablation or splanchnic sympa-thetic denervation. Collectively, our findings indicate that the carotid body detects circulating TNF-alpha to activate a counteracting sympathetic anti-inflammatory mechanism. (AU) | |
| Processo FAPESP: | 19/11196-0 - Mecanismos e circuitos neurais envolvidos na interação entre inflamação periférica e simpatoexcitação na Hipertensão Renovascular |
| Beneficiário: | Pedro Lourenço Katayama |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 15/23467-7 - Fisiopatologia experimental: mecanismos centrais de controle cardiovascular e respiratório envolvidos em modelos experimentais de hipertensão e obesidade |
| Beneficiário: | Eduardo Colombari |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |