| Texto completo | |
| Autor(es): Mostrar menos - |
Marena, Gabriel Davi
;
Ramos, Matheus Aparecido dos Santos
;
Carvalho, Gabriela Correa
;
Paris Junior, Jose Alberto
;
Resende, Flavia Aparecida
;
Correa, Ione
;
Ono, Gabriela Yuki Bressanim
;
Sousa Araujo, Victor Hugo
;
de Camargo, Bruna Almeida Furquim
;
Bauab, Tais Maria
;
Chorilli, Marlus
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Phytotherapy Research; v. 36, n. 7, p. 36-pg., 2022-05-29. |
| Resumo | |
Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a high capacity to acquire resistance to available therapy. The main resistance factors are the emergence of new strains and the uncontrolled use of antifungals. It is, therefore, important to develop new methods that contribute to combating fungal diseases in the clinical area. Natural products have considerable potential for the development of new drugs with antifungal activity, mainly due to their biocompatibility and low toxic effect. This promising antimicrobial activity of natural products is mainly due to the presence of flavonoids, terpenes, and quinones, which explains their antifungal potential. Pharmaceutical nanotechnology has been explored to enhance the delivery, selectivity, and clinical efficacy of these products. Nanotechnological systems provide a safe and selective environment for various substances, such as natural products, improving antifungal activity. However, further safety experiments (in vivo or clinical trials) need to be carried out to prove the therapeutic action of natural products, since they may have undesirable, toxic, and mutagenic effects. Therefore, this review article addresses the main nanotechnological methods using natural products for effective future treatment against the main fungal diseases. (AU) | |
| Processo FAPESP: | 18/23442-2 - Avaliação do potencial de lipossomas para co-encapsulação de anfotericina B e micafungina no tratamento de infecção sistêmica causada por Candida auris |
| Beneficiário: | Matheus Aparecido dos Santos Ramos |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar |
| Beneficiário: | Maria Vitória Lopes Badra Bentley |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/09831-9 - Nanoemulsões para co-encapsulação de anfotericina B e micafungina: desenvolvimento, caracterização e avaliação do potencial in vitro e in vivo contra Candida auris |
| Beneficiário: | Gabriel Davi Marena |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |