Association between coffee consumption with serum lipid profile in ELSA-Brasil study: a metabolomic approach

Autor(es)

Miranda, Andreia Machado ; Goulart, Alessandra Carvalho ; Generoso, Giuliano ; Bittencourt, Marcio Sommer ; Santos, Raul Dias ; Toth, Peter P. ; Jones, Stevens R. ; Bensenor, Isabela M. ; Lotufo, Paulo A. ; Marchioni, Dirce Maria

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF NUTRITION; v. 61, n. 8, p. 10-pg., 2022-07-27.

Resumo

Purpose This study evaluated the association between coffee consumption and serum lipid profile in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods This is a cross-sectional study on baseline data from participants of the cohort ELSA-Brasil. Only participants of Sao Paulo Research Center who underwent a nuclear magnetic resonance (NMR) spectroscopy examination of lipid profile were included (N = 4736). Coffee intake was categorized into four categories (cups/day, in reference cup size of 50 mL, which is the household measure adopted in Brazil): never/almost never, <= 1, 1-3, and > 3. Serum lipid profile [i.e., Total Cholesterol (TC), Total Triglycerides (TG), Very Low-Density Lipoprotein-cholesterol (VLDL-c), Low-Density Lipoprotein-cholesterol (LDL-c), High-Density Lipoprotein-cholesterol (HDL-c), Triglyceride-rich Lipoprotein Particles (TRLP) and subfractions particles] was analyzed. To estimate the effect of coffee consumption on serum lipid profile, multivariate Generalized Linear Models were performed. Results Compared to participants who never or almost never drink coffee, individuals who consumed more than 3 cups/day showed an increase in concentrations of TC (beta: 4.13; 95% CI 0.81, 7.45), TG (beta: 9.53; 95% CI 1.65, 17.42), VLDL-c (beta: 1.90; 95% CI 0.38, 3.42), TRLP (beta: 8.42; 95% CI 1.24, 15.60), and Very Small-TRLP and Medium-TRLP subfractions (beta: 7.36; 95% CI 0.21, 14.51; beta: 2.53; 95% CI 0.89, 4.16, respectively), but not with HDL-c and LDL-c. Among individuals with low (<= 1 cup/day) and moderate (1-3 cups/day) coffee consumption, no significant associations with lipids was observed. Conclusion High coffee consumption (more than 3 cups per day) was associated with an increase in serum lipids, namely TC, TG, VLDL-c, and TRL particles, highlighting the importance of a moderate consumption of this beverage. (AU)

• Processo FAPESP: 18/04116-7 - Efeito do Consumo de Café no risco de Hipertensão Arterial em Indivíduos Saudáveis e na Sobrevida após Síndrome Coronariana Aguda: Análise de Estudos Longitudinais
• Beneficiário: Andreia Alexandra Machado Miranda
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/12256-4 - Escore de cálcio e anatomia coronariana na identificação de risco de doença coronariana no Estudo Longitudinal de Saúde do Adulto (ELSA-Brasil)
• Beneficiário: Paulo Andrade Lotufo
• Modalidade de apoio: Auxílio à Pesquisa - Regular