Long-term reproductive effects of benzo(a)pyrene at environmentally relevant dose on juvenile female rats

Autor(es)

Reis, Ana Carolina Casali ; Jorge, Barbara Campos ; Paschoalini, Beatriz Rizzo ; Bueno, Jessica Nogueira ; Stein, Julia ; Moreira, Suyane da Silva ; Manoel, Beatriz de Manoel ; Fernandes, Glaura Scantamburlo Alves ; Hisano, Hamilton ; Arena, Arielle Cristina

• Tipo de documento: Artigo Científico
• Fonte: DRUG AND CHEMICAL TOXICOLOGY; v. N/A, p. 9-pg., 2022-07-29.

Resumo

Since studies on the reproductive consequences after the exposure to environmentally relevant doses of Benzo(a)pyrene (BaP) during critical stages of development are scarce, this study evaluated female reproductive parameters of adult rats exposed to a low dose of BaP during the juvenile phase. Female rats (Post-natal 21) were treated with BaP (0 or 0.1 mu g/kg/day; gavage) for 21 consecutive days. During the treatment, no clinical signs of toxicity were observed. Nevertheless, the ages of vaginal opening and first estrus were anticipated by the BaP-exposure. At the sexual maturity, the juvenile exposure compromised the sexual behavior, as well as the placental efficiency, follicle stimulating hormone levels, placenta histological analysis, and ovarian follicle count. A decrease in erythrocyte, platelet, and lymphocyte counts also was observed in the exposed-females. Moreover, the dose of BaP used in this study was not able to produce estrogenic activity in vivo. These data showed that juvenile BaP-exposure, at environmentally relevant dose, compromised the female reproductive system, possibly by an endocrine deregulation; however, this requires further investigation. (AU)

• Processo FAPESP: 17/22176-4 - Exposição ao Benzo(a)pireno em ratos machos púberes: repercussões tardias em parâmetros reprodutivos
• Beneficiário: Ana Carolina Casali Reis
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 19/03284-6 - O impacto da exposição paterna ao benzo(a)pireno da fase juvenil a peripuberdade em ratos: efeitos multigeracional e transgeracional em parâmetros reprodutivos
• Beneficiário: Arielle Cristina Arena
• Modalidade de apoio: Auxílio à Pesquisa - Regular