| Texto completo | |
| Autor(es): |
Pereira, Anieli G.
;
Grizante, Mariana B.
;
Kohlsdorf, Tiana
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES; v. 289, n. 1981, p. 10-pg., 2022-08-31. |
| Resumo | |
Developmental pathways encompass transcription factors and cis-regulatory elements that interact as transcription factor-regulatory element (TF-RE) units. Independent origins of similar phenotypes likely involve changes in different parts of these units, a hypothesis promisingly tested addressing the evolution of the rib-associated lumbar (RAL) morphotype that characterizes emblematic animals such as snakes and elephants. Previous investigation in these lineages identified a polymorphism in the Homology region 1 [H1] enhancer of the Myogenic factor-5 [Myf5], which interacts with HOX10 proteins to modulate rib development. Here we address the evolution of TF-RE units focusing on independent origins of RAL morphotypes. We compiled an extensive database for H1-Myf5 and HOX10 sequences with two goals: (i) evaluate if the enhancer polymorphism is present in amphibians exhibiting the RAL morphotype and (ii) test a hypothesis of enhanced evolutionary flexibility mediated by TF-RE units, according to which independent origins of the RAL morphotype might involve changes in either component of the interaction unit. We identified the H1-Myf5 polymorphism in lineages that diverged around 340 Ma, including Lissamphibia. Independent origins of the RAL morphotype in Tetrapoda involved sequence variation in either component of the TF-RE unit, confirming that different changes may similarly affect the phenotypic outcome of a given developmental pathway. (AU) | |
| Processo FAPESP: | 10/00447-7 - Evolução de morfologias convergentes em Squamata: módulos de desenvolvimento e padrões de alongamento corporal |
| Beneficiário: | Mariana Bortoletto Grizante |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 15/07650-6 - Ecologia, evolução e desenvolvimento (Eco-Evo-Devo) na herpetofauna brasileira |
| Beneficiário: | Tiana Kohlsdorf |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 20/14780-1 - Evo-Devo em ambientes dinâmicos: implicações das mudanças climáticas na biodiversidade |
| Beneficiário: | Tiana Kohlsdorf |
| Modalidade de apoio: | Auxílio à Pesquisa - Programa BIOTA - Temático |
| Processo FAPESP: | 19/21712-5 - Evolução molecular de genes HOX: existem padrões genéticos convergentes nas múltiplas origens do fenótipo serpentiforme em Tetrapoda? |
| Beneficiário: | Anieli Guirro Pereira |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |