| Texto completo | |
| Autor(es): |
Bonidia, Robson P.
;
Avila Santos, Anderson P.
;
de Almeida, Breno L. S.
;
Stadler, Peter F.
;
da Rocha, Ulisses Nunes
;
Sanches, Danilo S.
;
de Carvalho, Andre C. P. L. F.
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Entropy; v. 24, n. 10, p. 17-pg., 2022-10-01. |
| Resumo | |
In recent years, there has been an exponential growth in sequencing projects due to accelerated technological advances, leading to a significant increase in the amount of data and resulting in new challenges for biological sequence analysis. Consequently, the use of techniques capable of analyzing large amounts of data has been explored, such as machine learning (ML) algorithms. ML algorithms are being used to analyze and classify biological sequences, despite the intrinsic difficulty in extracting and finding representative biological sequence methods suitable for them. Thereby, extracting numerical features to represent sequences makes it statistically feasible to use universal concepts from Information Theory, such as Tsallis and Shannon entropy. In this study, we propose a novel Tsallis entropy-based feature extractor to provide useful information to classify biological sequences. To assess its relevance, we prepared five case studies: (1) an analysis of the entropic index q; (2) performance testing of the best entropic indices on new datasets; (3) a comparison made with Shannon entropy and (4) generalized entropies; (5) an investigation of the Tsallis entropy in the context of dimensionality reduction. As a result, our proposal proved to be effective, being superior to Shannon entropy and robust in terms of generalization, and also potentially representative for collecting information in fewer dimensions compared with methods such as Singular Value Decomposition and Uniform Manifold Approximation and Projection. (AU) | |
| Processo FAPESP: | 13/07375-0 - CeMEAI - Centro de Ciências Matemáticas Aplicadas à Indústria |
| Beneficiário: | Francisco Louzada Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs |
| Processo FAPESP: | 21/08561-8 - Classificação e análise de sequências bacterianas de RNA não-codificante com a utilização de técnicas de aprendizado de máquina |
| Beneficiário: | Breno Livio Silva de Almeida |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |