| Texto completo | |
| Autor(es): Mostrar menos - |
Vega, Maite Duhalde
;
Olivera, Daniela
;
Davanzo, Gustavo Gastao
;
Bertullo, Mauricio
;
Noya, Veronica
;
de Souza, Gabriela Fabiano
;
Muraro, Stefanie Primon
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Castro, Icaro
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Arevalo, Ana Paula
;
Crispo, Martina
;
Galliussi, German
;
Russo, Sofia
;
Charbonnier, David
;
Rammauro, Florencia
;
Jeldres, Mathias
;
Alamon, Catalina
;
Varela, Valentina
;
Batthyany, Carlos
;
Bollati-Fogolin, Mariela
;
Oppezzo, Pablo
;
Pritsch, Otto
;
Proenca-Modena, Jose Luiz
;
Nakaya, Helder I.
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Trias, Emiliano
;
Barbeito, Luis
;
Anegon, Ignacio
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Cuturi, Maria Cristina
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Moraes-Vieira, Pedro
;
Segovia, Mercedes
;
Hill, Marcelo
Número total de Autores: 30
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| Tipo de documento: | Artigo Científico |
| Fonte: | SCIENCE ADVANCES; v. 8, n. 38, p. 13-pg., 2022-09-23. |
| Resumo | |
Severe COVID-19 is associated with hyperinflammation and weak T cell responses against SARS-CoV-2. However, the links between those processes remain partially characterized. Moreover, whether and how therapeutically manipulating T cells may benefit patients are unknown. Our genetic and pharmacological evidence demonstrates that the ion channel TMEM176B inhibited inflammasome activation triggered by SARS-CoV-2 and SARS-CoV-2-related murine beta-coronavirus. Tmem176b(-/-) mice infected with murine beta-coronavirus developed inflammasome-dependent T cell dysfunction and critical disease, which was controlled by modulating dysfunctional T cells with PD-1 blockers. In critical COVID-19, inflammasome activation correlated with dysfunctional T cells and low monocytic TMEM176B expression, whereas PD-L1 blockade rescued T cell functionality. Here, we mechanistically link T cell dysfunction and inflammation, supporting a cancer immunotherapy to reinforce T cell immunity in critical beta-coronavirus disease. (AU) | |
| Processo FAPESP: | 20/04558-0 - Caracterização de fatores de risco intrínsecos e o desenvolvimento de novas alternativas de diagnóstico e tratamento para COVID-19 |
| Beneficiário: | José Luiz Proença Módena |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 20/04579-7 - Estudo sobre fatores de risco associados à maior gravidade a COVID-19 e mapeamento de vias metabólicas necessárias para a resposta anti-SARS-CoV-2 |
| Beneficiário: | Pedro Manoel Mendes de Moraes Vieira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |