| Texto completo | |
| Autor(es): Mostrar menos - |
Nobrega, Guilherme M.
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Guida, Jose P.
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Novaes, Juliana M.
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Solda, Larissa M.
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Pietro, Luciana
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Luz, Adriana G.
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Lajos, Giuliane J.
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Ribeiro-do-Valle, Carolina C.
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Souza, Renato
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Cecatti, Jose G.
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Mysorekar, Indira U.
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Dias, Tabata Z.
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Costa, Maria Laura
Número total de Autores: 13
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| Tipo de documento: | Artigo Científico |
| Fonte: | PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH; v. 31, p. 6-pg., 2022-12-14. |
| Resumo | |
Objectives: To analyze soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factors (PlGF) concen-trations and their ratio in pregnant and postpartum women with suspected COVID-19, and further investigate conditions associated with an increased ratio (sFlt-1/PlGF > 38), including preeclampsia (PE) and severe acute respiratory syndrome (SARS). Study Design: The present study is a secondary analysis of a prospective cohort. Blood samples were collected at time of COVID-19 investigation and the serum measurements of sFlt-1 and PlGF were performed. Clinical background, SARS-CoV-2 infection characteristics, maternal and perinatal outcomes were further analyzed. Main outcome measures: Serum measurements of sFlt-1 and PlGF; obstetrics and clinical outcomes. Results: A total of 97 SARS-CoV-2 unvaccinated women with suspected infection were considered, 76 were COVID-19 positive cases and 21 COVID-19 negative. Among COVID-19 positive cases, 09 presented with SARS and 11 were diagnosed with PE, of which 6 had SARS-CoV-2 infection in first and second trimester (04 with sFlt-1/PlGF >= 38) and 05 with PE and COVID-19 diagnosed at the same time, during third trimester (03 with sFlt-1/ PlGF >= 38). Five presented with PE with severe features. sFlt-1/PlGF ratio was significantly higher in the COVID-19 positive/PE positive group compared to COVID-19 positive/PE negative group (p-value = 0.005), with no increase in cases complicated by SARS. Conclusions: sFlt-1/PlGF ratio could be a useful tool for differential diagnosis and adequate counseling among cases of COVID-19 and PE, especially if severe disease. COVID-19 early in pregnancy could potentially be a risk factor for PE later during gestation. (AU) | |
| Processo FAPESP: | 21/09937-1 - COVID-19 e pré-eclâmpsia: causa ou consequência? |
| Beneficiário: | Maria Laura Costa do Nascimento |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |