Daily rhythm of dynamic cerebral autoregulation in patients after stroke

Autor(es)

Abadjiev, Daniel S. ; Toschi-Dias, Edgar ; Salinet, Angela S. M. ; Gaykova, Nicole N. ; Lo, Men-Tzung ; Nogueira, Ricardo C. ; Hu, Kun

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM; v. N/A, p. 10-pg., 2023-02-01.

Resumo

Dynamic cerebral autoregulation (dCA) in healthy young adults displays a daily variation. Whether the rhythm exists in patients with stroke is unknown. We studied 28 stroke patients (age: 26-83 years, 7 females) within 48 hours after thrombolysis. dCA was assessed 54 times in these patients during supine rest (twice in 26 and once in 2 patients): 9 assessments between 0-9AM, 12 between 9AM-2PM, 20 between 2-7PM, and 13 between 7PM-12AM. To estimate dCA, phase shifts between spontaneous oscillations of cerebral blood flow velocity (CBFV) in the middle cerebral artery and arterial blood pressure (BP) were obtained in four frequency bands: <0.05 Hz, 0.05-0.1 Hz, 0.1-0.2 Hz, and >0.2 Hz. CBFV-BP phase shifts at <0.05 Hz were significantly larger between 2-7PM, suggesting better dCA, than those at other times (p < 0.0001), and the daily rhythm was consistent for stroke and non-stroke sides. No significant rhythms were observed at higher frequencies (all p > 0.2). All results were independent of age, sex, stroke type and severity, and other cardiovascular conditions. dCA after stroke showed a daily rhythm, leading to a better regulation of CBFV at <0.05 Hz during the afternoon. The finding may have implications for daily activity management of stroke patients. (AU)

• Processo FAPESP: 21/03076-4 - Prevenção do acidente vascular cerebral por meio da estimulação não invasiva do nervo vago: um ensaio piloto randomizado controlado
• Beneficiário: Edgar Toschi Dias
• Modalidade de apoio: Auxílio à Pesquisa - Regular