| Texto completo | |
| Autor(es): |
Oliveira Souza, Marilia Cristina
;
Rocha, Bruno Alves
;
Bianchi Ximenez, Joao Paulo
;
Devoz, Paula Picoli
;
Santana, Anthony
;
Campiglia, Andres Dobal
;
Barbosa Jr, Fernando
Número total de Autores: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Environmental Science and Pollution Research; v. 29, n. 31, p. 12-pg., 2022-02-18. |
| Resumo | |
Monitoring human exposure to polycyclic aromatic hydrocarbons (PAHs) is a public health concern. Children are a vulnerable subgroup of the population with limited human biomonitoring data worldwide. Thus, this study aimed to measure the levels of seven PAH metabolites in urine from Brazilian children and provide risk assessment values for this exposure. Our data show naphthalene was the major contributor to children's exposure to PAHs, with a 100% detection rate. Children in urban regions presented higher exposure to PAHs, with higher concentrations of 2-naphthol in the southeast (1.09 ng/mL, p < 0.05). Furthermore, the highest concentration of 2-naphthol was found in older children (p = 0.02), suggesting a possible difference in dietary habits. Exposure to the carbaryl insecticide is suggested based on the high concentrations of 1-naphthol (1.29 ng/mL) and considering the ratio 1-naphthol/2-naphthol (1.78). Moreover, the positive correlation between the metabolites of fluorine and pyrene also suggests exposure to PAHs by petrol combustion. The risk assessment of the PAH exposure was evaluated using the estimated daily intake (EDI) for two naphthalene metabolites in the study with a 100% detection rate. The EDI was 14.47 ng/kg BW/day. The risk assessment to the PAH exposure revealed a non-carcinogenic risk profile, with a hazard quotient of 0.71. To the best of our knowledge, this study is the first to provide levels of PAHs in Brazilian children. (AU) | |
| Processo FAPESP: | 18/24069-3 - Do biomonitoramento ao reconhecimento de assinaturas do exposoma humano visando antecipar riscos para uma saúde contínua |
| Beneficiário: | Fernando Barbosa Júnior |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 19/07161-6 - Avaliação da exposição a praguicidas, hidrocarbonetos policíclicos aromáticos e metais tóxicos em crianças brasileiras: estabelecimento de valores de referência e possível associação com marcadores de estresse oxidativo. |
| Beneficiário: | Marília Cristina Oliveira Souza |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 21/03633-0 - Desenvolvimento e aplicação de métodos analíticos simples e rápidos para a determinação de desreguladores endócrinos e biomarcadores de estresse oxidativo em amostras biológicas para avaliação da exposição de crianças e gestantes |
| Beneficiário: | Bruno Alves Rocha |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |