The role of the oviduct and extracellular vesicles during early embryo development in bovine

Autor(es)

Bastos, Natalia Marins ; Ferst, Juliana Germano ; Goulart, Rodrigo Silva ; da Silveira, Juliano Coelho

• Tipo de documento: Artigo Científico
• Fonte: ANIMAL REPRODUCTION; v. 19, n. 1, p. 13-pg., 2022-01-01.

Resumo

The oviduct is an important reproductive structure that connects the ovary to the uterus and takes place to important events such as oocyte final maturation, fertilization and early embryonic development. Thus, gametes and embryo can be directly influenced by the oviductal microenvironment composed by epithelial cells such secretory and ciliated cells and oviductal fluid. The oviduct composition is anatomically dynamic and is under ovarian hormones control. The oviductal fluid provides protection, nourishment and transport to gametes and embryo and allows interaction to oviductal epithelial cells. All these functions together allows the oviduct to provides the ideal environment to the early reproductive events. Extracellular vesicles (EVs) are biological nanoparticles that mediates cell communication and are present at oviductal fluid and plays an important role in gametes/embryo -oviductal cells communication. This review will present the ability of the oviducts based on its dynamic and systemic changes during reproductive events, as well as the contribution of EVs in this process. (AU)

• Processo FAPESP: 14/22887-0 - Exossomos e microvesículas contendo miRNAs modulam mudanças epigenéticas durante o cultivo in vitro de gametas e embriões em bovinos
• Beneficiário: Juliano Coelho da Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 20/08478-0 - Influências hormonais e da reserva energética corporal na modulação do ambiente reprodutivo intrafolicular e periconcepcional
• Beneficiário: Juliano Coelho da Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 15/21829-9 - EMU concedido no projeto 2014/22887-0: NanoSight LM10
• Beneficiário: Juliano Coelho da Silveira
• Modalidade de apoio: Auxílio à Pesquisa - Programa Equipamentos Multiusuários
• Processo FAPESP: 20/13075-2 - Efeito do status metabólico de vacas de leite nas mudanças epigenéticas no embrião e endometrio e o papel de vesículas extracelulares
• Beneficiário: Juliana Germano Ferst
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado