Autor(es)

Neves Borgheti-Cardoso, Livia ; Rosa Viegas, Juliana Santos ; Pupo Silvestrini, Ana Vitoria ; Caron, Angelo Luis ; Praca, Fabiola Garcia ; Kravicz, Marcelo ; Lopes Badra Bentley, Maria Vitoria

• Tipo de documento: Artigo Científico
• Fonte: Advanced Drug Delivery Reviews; v. 153, p. 28-pg., 2020-01-01.

Resumo

Skin cancer is a high burden disease with a high impact on global health. Conventional therapies have several drawbacks; thus, the development of effective therapies is required. In this context, nanotechnology approaches are an attractive strategy for cancer therapy because they enable the efficient delivery of drugs and other bioactive molecules to target tissues with low toxic effects. In this review, nanotechnological tools for skin cancer will be summarized and discussed. First, pathology and conventional therapies will be presented, followed by the challenges of skin cancer therapy. Then, the main features of developing efficient nanosystems will be discussed, and next, the most commonly used nanoparticles (NPs) described in the literature for skin cancer therapy will presented. Subsequently, the use of NPs to deliver chemotherapeutics, immune and vaccine molecules and nucleic acids will be reviewed and discussed as will the combination of physical methods and NPs. Finally, multifunctional delivery systems to codeliver anticancer therapeutic agents containing or not surface functionalization will be summarized. (c) 2020 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 19/04448-2 - Desenvolvimento de carreador lipídico nanoestruturado contendo pool de siRNAs associados à agente antitumoral como uma abordagem terapêutica multifuncional para o Câncer de pele
• Beneficiário: Juliana dos Santos Rosa
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/50928-2 - INCT 2014: Nanotecnologia Farmacêutica: uma abordagem transdisciplinar
• Beneficiário: Maria Vitória Lopes Badra Bentley
• Modalidade de apoio: Auxílio à Pesquisa - Temático