Clinical predictors of malignant transformation and recurrence in oral potentially malignant disorders: A systematic review and meta-analysis

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Paglioni, Mariana de Pauli ; Khurram, Syed Ali ; Ruiz, Blanca Iciar Indave ; Lauby-Secretan, Beatrice ; Normando, Ana Gabriela ; Prado Ribeiro, Ana Carolina ; Brandao, Thais Bianca ; Palmier, Natalia Rangel ; Lopes, Marcio Ajudarte ; da Silva Guerra, Eliete Neves ; Meleti, Marco ; Migliorati, Cesar Augusto ; Carvalho, Andre Lopes ; de Matos, Leandro Luongo ; Kowalski, Luiz Paulo ; Santos-Silva, Alan Roger

• Tipo de documento: Artigo Científico
• Fonte: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 134, n. 5, p. 15-pg., 2022-11-28.

Resumo

Objective. We performed a systematic review dedicated to pooling evidence for the associations of clinical features with malignant transformation (MT) and recurrence of 3 oral potentially malignant disorders (OPMDs) (actinic cheilitis [AC], oral leukoplakia [OL], and proliferative verrucous leukoplakia [PVL]). Study Design. We selected studies that included clinical features and risk factors (age, sex, site, size, appearance, alcohol intake, tobacco use, and sun exposure) of OL, PVL, and AC associated with recurrence and/or MT. Results. Based on the meta-analysis results, non-homogeneous OL appears to have a 4.53 times higher chance of recurrence after treatment. We also found 6.52 higher chances of MT of non-homogeneous OL. Another clinical feature related to higher MT chances is the location (floor of the mouth and tongue has 4.48 higher chances) and the size (OL with >200 mm2 in size has 4.10 higher chances of MT). Regarding habits, nonsmoking patients with OL have a 3.20 higher chance of MT. The only clinical feature related to higher chances of MT in patients with PVL was sex (females have a 2.50 higher chance of MT). Conclusions. Our study showed that some clinical features may indicate greater chances of recurrence after treatment and MT of OPMD. (AU)

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