Inflammatory cytokines and chemokines in obese adolescents with antibody against to adenovirus 36

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Sanches, Marcelo D'Alessandre ; Goldberg, Tamara Beres Lederer ; Rizzo, Anapaula da Conceicao Bisi ; da Silva, Valeria Nobrega ; Mosca, Luciana Nunes ; Romagnoli, Graziela Gorete ; Gorgulho, Carolina Mendonca ; Araujo Junior, Joao Pessoa ; de Lima, Gustavo Ramos ; Betti, Isabella Rodrigues ; Kurokawa, Cilmery Suemi

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 13, n. 1, p. 9-pg., 2023-06-19.

Resumo

Obesity in adolescents has reached epidemic proportions and is associated with the inflammatory response and viral infections. The aim of this study was to understand the profile of inflammatory cytokines and chemokines associated with the inflammatory response and metabolic syndrome (MetS) in obese adolescents with positive serology for adenovirus 36 (ADV36). Thirty-six overweight, 36 obese, and 25 severe obesity adolescents aged 10 to 16 years were included in the study. The following variables were analyzed: sex, age, body mass index (BMI), blood pressure, total cholesterol and fractions, triglycerides, glucose, serum cytokine concentrations, and ADV36 antibodies. Cytokines and chemokines were quantified by cytometry and ADV36 serology was determined by enzyme-linked immunosorbent assay (ELISA). The results showed higher levels of the cytokines interleukin-1beta (IL-1 & beta;), IL-6, IL-10 and of the chemokine interferon-gamma-inducible protein 10 (IP-10) in severe obesity adolescents compared to the obese and overweight groups, as well as in the group with MetS compared to the group without this syndrome. The frequency of ADV36-positive individuals did not differ between groups. The findings revealed differences in BMI between the obese and severe obesity groups versus the overweight group in the presence of positivity for ADV36, suggesting an association with weight gain and possibly MetS installation. (AU)

• Processo FAPESP: 14/24345-0 - Citocinas inflamatórias de macrófagos M1 e associação com IgG anti-adenovírus 36 em adolescentes obesos
• Beneficiário: Cilmery Suemi Kurokawa
• Modalidade de apoio: Auxílio à Pesquisa - Regular