| Texto completo | |
| Autor(es): Mostrar menos - |
Cousseau, Cristiane Pereira Vargas
;
Sorroche, Bruna Pereira
;
Teixeira, Renan de Jesus
;
de Carvalho, Ana Carolina
;
Melendez, Matias Eliseo
;
Capuzzo, Renato de Castro
;
Laus, Ana Carolina
;
da Silva, Luciane Sussuchi
;
de Menezes, Nei Soares
;
Carvalho, Andre Lopes
;
Arantes, Lidia Maria Rebolho Batista
Número total de Autores: 11
|
| Tipo de documento: | Artigo Científico |
| Fonte: | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK; v. N/A, p. 9-pg., 2023-07-31. |
| Resumo | |
BackgroundMetastatic lymph node involvement influences therapy decisions and serves as a prognostic indicator in oral squamous cell carcinoma (OSCC). However, many early-stage patients with clinically negative lymph nodes exhibit no metastasis upon surgical staging. This study aimed to identify differentially expressed miRNAs capable of distinguishing pathologically positive (pN+) from negative (pN0) nodes in OSCC patients without clinical evidence of lymph node metastases (cN0). MethodsExpression levels of 798 miRNAs were assessed in tumor samples from 10 pN+ and 10 pN0 patients using the Nanostring nCounter platform. Validation was performed in an independent cohort of 15 pN+ and 24 pN0 patients through RT-qPCR. ResultsEight miRNAs exhibited differential expression between pN0 and pN+ patients. Notably, hsa-miR-99a-5p demonstrated high sensitivity and specificity in predicting patients at higher risk of positive lymph nodes. ConclusionsThese findings highlight hsa-miR-99a-5p as a potential biomarker for detecting lymph node metastasis in primary OSCC tumors. (AU) | |
| Processo FAPESP: | 16/03706-0 - Avaliação do perfil de metilação de promotores gênicos em margens cirúrgicas de pacientes com carcinoma de células escamosas da cavidade oral |
| Beneficiário: | Bruna Pereira Sorroche |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |