| Texto completo | |
| Autor(es): Mostrar menos - |
da Silva, Luana Laura Sales
;
Barbosa, Jessica Anastacia Silva
;
Joao, Juliana Morelli Lopes Goncalves
;
Fukuzaki, Silvia
;
Camargo, Leandro do Nascimento
;
dos Santos, Tabata Maruyama
;
de Campos, Elaine Cristina
;
Costa, Arthur Silva
;
Saraiva-Romanholo, Beatriz Mangueira
;
Bezerra, Suellen Karoline Moreira
;
Lopes, Fernanda Tenorio Quirino dos Santos
;
Bonturi, Camila Ramalho
;
Oliva, Maria Luiza Vilela
;
Leick, Edna Aparecida
;
Righetti, Renato Fraga
;
Tiberio, Iolanda de Fatima Lopes Calvo
Número total de Autores: 16
|
| Tipo de documento: | Artigo Científico |
| Fonte: | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 24, n. 14, p. 26-pg., 2023-07-01. |
| Resumo | |
(1) There are several patients with asthma-COPD overlap (ACO). A peptide derived from the primary sequence of a kallikrein inhibitor isolated from Bauhinia bauhinioides (pep-BbKI) has potent anti-inflammatory and antioxidant effects. Purpose: To investigate the effects of pep-BbKI treatment in an ACO model and compare them with those of corticosteroids. (2) BALB/c mice were divided into groups: SAL (saline), OVA (ovalbumin), ELA (elastase), ACO (ovalbumin + elastase), ACO-pep-BbKI (treated with inhibitor), ACO-DX (dexamethasone treatment), ACO-DX-pep-BbKI (both treatments), and SAL-pep-BbKI (saline group treated with inhibitor). We evaluated: hyperresponsiveness to methacholine, bronchoalveolar lavage fluid (BALF), exhaled nitric oxide (eNO), IL-1 & beta;, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, IFN-& gamma;, TNF-& alpha;, MMP-9, MMP-12, TGF-& beta;, collagen fibers, iNOS, eNO, linear mean intercept (Lm), and NF-& kappa;B in airways (AW) and alveolar septa (AS). (3) ACO-pep-BbKI reversed ACO alterations and was similar to SAL in all mechanical parameters, Lm, neutrophils, IL-5, IL-10, IL-17, IFN-& gamma;, TNF-& alpha;, MMP-12 (AW), collagen fibers, iNOS (AW), and eNO (p > 0.05). ACO-DX reversed ACO alterations and was similar to SAL in all mechanical parameters, Lm, total cells and differentials, IL-1 & beta;(AS), IL-5 (AS), IL-6 (AS), IL-10 (AS), IL-13 (AS), IFN-& gamma;, MMP-12 (AS), TGF-& beta; (AS), collagen fibers (AW), iNOS, and eNO (p > 0.05). SAL was similar to SAL-pep-BbKI for all comparisons (p > 0.05). (4) Pep-BbKI was similar to dexamethasone in reducing the majority of alterations of this ACO model. (AU) | |
| Processo FAPESP: | 18/02537-5 - Caracterização da síndrome de sobreposição asma-DPOC (ACOS): estudos experimentais e clínicos |
| Beneficiário: | Iolanda de Fátima Lopes Calvo Tibério |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |