Recombinant antigen delivery to dendritic cells as a way to improve vaccine design

Autor(es)

de Souza-Silva, Guilherme Antonio ; Sulczewski, Fernando Bandeira ; Boscardin, Silvia Beatriz

• Tipo de documento: Artigo Científico
• Fonte: Experimental Biology and Medicine; v. N/A, p. 8-pg., 2023-09-25.

Resumo

Dendritic cells are central to the development of immunity, as they are specialized in initiating antigen-specific immune responses. In this review, we briefly present the existing knowledge on dendritic cell biology and how their division in different dendritic cell subsets may impact the development of immune responses. In addition, we explore the use of chimeric monoclonal antibodies that bind to dendritic cell surface receptors, with an emphasis on the C-type lectin family of endocytic receptors, to deliver antigens directly to these cells. Promising preclinical studies have shown that it is possible to modulate the development of immune responses to different pathogens when monoclonal antibodies fused to pathogen-derived antigens are used to deliver the antigen to different subsets of dendritic cells. This approach can be used to improve the efficacy of vaccines against different pathogens. (AU)

• Processo FAPESP: 22/00204-4 - Influência da via de sinalização de STAT5 em células dendríticas convencionais na instrução da resposta de células T auxiliares
• Beneficiário: Guilherme Antonio de Souza Silva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto
• Processo FAPESP: 18/00145-2 - Influência das vias de sinalização de STAT1, STAT3, STAT5 e STAT6 em células dendríticas convencionais na instrução da resposta de células T auxiliares
• Beneficiário: Fernando Bandeira Sulczewski
• Modalidade de apoio: Bolsas no Brasil - Doutorado