Gut-microbiome-brain axis: the crosstalk between the vagus nerve, alpha-synuclein and the brain in Parkinson's disease

Autor(es)

Claudino dos Santos, Julio Cesar ; Oliveira, Leandro Freitas ; Noleto, Felipe Micelli ; Pinheiro Gusmao, Camilla Teixeira ; de Castro Brito, Gerly Anne ; de Barros Viana, Glauce Socorro

• Tipo de documento: Artigo Científico
• Fonte: NEURAL REGENERATION RESEARCH; v. 18, n. 12, p. 4-pg., 2023-12-01.

Resumo

This critical review of the literature shows that there is a close link between the microbiome, the gut, and the brain in Parkinson's disease. The vagus nerve, the main component of the parasympathetic nervous system, is involved in the regulation of immune response, digestion, heart rate, and control of mood. It can detect microbiota metabolites through its afferents, transferring this gut information to the central nervous system. Preclinical and clinical studies have shown the important role played by the gut microbiome and gut-related factors in disease development and progression, as well as treatment responses. These findings suggest that the gut microbiome may be a valuable target for new therapeutic strategies for Parkinson's disease. More studies are needed to better understand the underlying biology and how this axis can be modulated for the patient's benefit. (AU)

• Processo FAPESP: 21/06473-4 - Potencial terapêutico da fotobiomodulação em ratos com Epilepsia: análise da frequência de crises epilépticas, desempenho cognitivo, e perfil metabolômico cerebral
• Beneficiário: Fabrízio dos Santos Cardoso
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado