Estrogen Deficiency Impairs Osseointegration in Hypertensive Rats Even Treated with Alendronate Coated on the Implant Surface

Autor(es)

Mulinari-Santos, Gabriel ; dos Santos, Jaqueline Silva ; Kitagawa, Igor Lebedenco ; Batista, Fabio Roberto de Souza ; Botacin, Paulo Roberto ; Antoniali, Cristina ; Lisboa-Filho, Paulo Noronha ; Okamoto, Roberta

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF FUNCTIONAL BIOMATERIALS; v. 14, n. 9, p. 13-pg., 2023-09-01.

Resumo

Hypertension and estrogen deficiency can affect bone metabolism and therefore increase the risk of osseointegration. Antihypertensive drugs such as losartan not only control blood pressure but also enhance bone healing. In addition, alendronate sodium is widely used to treat postmenopausal osteoporosis. Hence, we evaluated the effect of systemic antihypertensive and local alendronate coted on implants on osseointegration under hypertensive and estrogen-deficiency conditions. A total of 64 spontaneously hypertensive rats (SHRs) treated with losartan were randomly divided according to the estrogen-deficiency induction by ovariectomy (OVX) or not (SHAM), and whether the implant surface was coated with sodium alendronate (ALE) or not, resulting in four groups: SHR SHAM, SHR SHAM ALE, SHR OVX, and SHR OVX ALE. The removal torque, microcomputed tomography, and epifluorescence microscopy were the adopted analyses. The hypertensive and estrogen-deficiency animals presented a lower removal torque even when treated with alendronate on implant surface. The microcomputed tomography revealed a higher bone volume and bone-to-implant contact in the SHRs than the SHR OVX rats. Epifluorescence showed a decreased mineral apposition ratio in the SHR OVX ALE group. The data presented indicate that estrogen deficiency impairs osseointegration in hypertensive rats; in addition, alendronate coated on the implant surface does not fully reverse this impaired condition caused by estrogen deficiency. (AU)

• Processo FAPESP: 17/16912-0 - Avaliação do comportamento de duas diferentes texturizações de superfície na osteogênese peri-implantar em ratos espontaneamente hipertensos (SHR) e tratados com losartan
• Beneficiário: Jaqueline Silva dos Santos
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 17/23082-3 - Caracterização do tecido ósseo peri-implantar em ratas hipertensas e com deficiência de estrógeno, após ação sinérgica de losartan e alendronato de sódio
• Beneficiário: Gabriel Mulinari dos Santos
• Modalidade de apoio: Bolsas no Brasil - Doutorado