Recent advances in electrochemical nanobiosensors for cardiac biomarkers

Autor(es)

Negahdary, Masoud ; Sharma, Abhinav ; Anthopoulos, Thomas D. ; Angnes, Lucio

• Tipo de documento: Artigo Científico
• Fonte: TRAC-TRENDS IN ANALYTICAL CHEMISTRY; v. 164, p. 22-pg., 2023-07-01.

Resumo

The WHO reports heart diseases, especially MI, are the leading cause of death. During a heart attack and damage to myocardial cells, cardiac biomarkers are released into the bloodstream. Their accurate mea-surement can be beneficial in the rapid screening of patients and the initiation of treatment. Rapid diagnosis of MI prevents secondary complications such as heart failure and will significantly reduce the mortality rate of patients. Electrochemical biosensors are cutting-edge diagnostic tools that successfully track the quantitative detection of several cardiac biomarkers. They are composed of three primary components: a biorecognition element, a signal transducer, and a detector. Here, the latest electro-chemical biosensors developed in 2021-2023 have been collected and categorized, and their main features have been reviewed, analyzed, and compared. The most crucial biorecognition elements used in these biosensors include antibodies, oligonucleotides (especially: aptamers), and peptide sequences that are specifically selected and used to detect analytes. Equipping electrochemical biosensors with nano -materials has increased diagnostic performance (especially sensitivity), facilitating reliable detection. These nanomaterials have been employed by modifying the surface of the signal transducer or opti-mizing the biorecognition element, or both. Investigating the most up-to-date platforms for detecting cardiac biomarkers and presenting their essential assembly features and diagnosis mechanisms can provide subsequent research avenues.& COPY; 2023 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 19/27021-4 - Projeto e fabricação de biossensores eletroquímicos para diagnóstico precoce de infarto do miocárdio e de Carcinoma Hepatocelular usando primers de microRNAs (miRNAs) como elemento de bioreconhecimento e arranjos de matrizes de nanoestruturas de ouro
• Beneficiário: Masoud Negahdary
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 17/13137-5 - Formação e propriedades de hemiésteres do ácido carbônico em meio aquoso
• Beneficiário: Claudimir Lucio Do Lago
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 14/50867-3 - INCT 2014: Instituto Nacional de Ciência e Tecnologia de Bioanalítica
• Beneficiário: Marco Aurelio Zezzi Arruda
• Modalidade de apoio: Auxílio à Pesquisa - Temático