Levodopa Facilitates Prefrontal Cortex Activation During Dual Task Walking in Parkinson Disease

Autor(es)

Orcioli-Silva, Diego ; Vitorio, Rodrigo ; Nobrega-Sousa, Priscila ; da Conceicao, Nubia Ribeiro ; Beretta, Victor Spiandor ; Lirani-Silva, Ellen ; Gobbi, Lilian Teresa Bucken

• Tipo de documento: Artigo Científico
• Fonte: NEUROREHABILITATION AND NEURAL REPAIR; v. 34, n. 7, p. 11-pg., 2020-05-25.

Resumo

Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investigate the effect of dopaminergic medication on PFC activity and gait parameters during dual task walking in people with PD. Methods. A total of 20 individuals with PD (69.8 +/- 5.9 years) and 30 healthy older people (68.0 +/- 5.6 years) performed 2 walking conditions: single and dual task (walking while performing a digit vigilance task). A mobile functional near infrared spectroscopy system and an electronic sensor carpet were used to analyze PFC activation and gait parameters, respectively. Relative concentrations of oxygenated hemoglobin (HbO(2)) from the left and right PFC were measured. Results. People with PD in the off state did not present changes in HbO(2) level in the left PFC across walking conditions. In contrast, in the on state, they presented increased HbO(2) levels during dual task compared with single task. Regardless of medication state, people with PD presented increased HbO(2) levels in the right PFC during dual task walking compared with single task. The control group demonstrated increased PFC activity in both hemispheres during dual task compared with single task. People with PD showed increases in both step length and velocity in the on state compared with the off state. Conclusions. PD limits the activation of the left PFC during dual task walking, and dopaminergic medication facilitates its recruitment. (AU)

• Processo FAPESP: 16/21499-1 - Atividade do córtex cerebral durante a locomoção humana: Influência do envelhecimento, da doença de Parkinson e do exercício físico agudo
• Beneficiário: Lilian Teresa Bucken Gobbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/22308-0 - Efeitos da Doença de Parkinson sobre medidas de eletroencefalografia durante o andar livre e a ultrapassagem de obstáculo
• Beneficiário: Rodrigo Vitório
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado