| Texto completo | |
| Autor(es): |
Ribeiro, Iris Renata Sousa
;
da Silva, Raquel Frenedoso
;
Rabelo, Renata Santos
;
Marin, Talita Miguel
;
Bettini, Jefferson
;
Cardoso, Mateus Borba
Número total de Autores: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ACS APPLIED MATERIALS & INTERFACES; v. 15, n. 30, p. 11-pg., 2023-07-19. |
| Resumo | |
Most nanomaterial-based medicines are intravenously appliedsinceoral administration comprises challenging-related biological obstacles,such as interactions with distinct digestive fluids and their transportthrough the intestinal barrier. Moreover, there is a lack of nanoparticle-basedstudies that faithfully consider the above-cited obstacles and boostoral-administered nanomedicines' rational design. In this study,the physicochemical stability of fluorescent model silica nanoparticles(f-SiO(2)NPs) passing through all simulated gastrointestinalfluids (salivary, gastric, and intestinal) and their absorption andtransport across a model human intestinal epithelium barrier are investigated.An aggregation/disaggregation f-SiO(2)NPs process is identified,although these particles remain chemically and physically stable afterexposure to digestive fluids. Further, fine imaging of f-SiO(2)NPs through the absorption and transport across the human intestinalepithelium indicates that nanoparticle transport is time-dependent.The above-presented protocol shows tremendous potential for decipheringfundamental gastrointestinal nanoparticles' evolution and cancontribute to rational oral administration-based nanomedicine design. (AU) | |
| Processo FAPESP: | 21/12071-6 - Arquitetando coloides via interações supramoleculares: de fundamentos a aplicações |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 15/25406-5 - Organizando a matéria: colóides formados por associação de surfactantes, polímeros e nanopartículas |
| Beneficiário: | Watson Loh |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |
| Processo FAPESP: | 17/21318-0 - Direcionamento de nanopartículas funcionalizadas em sistemas microfluídicos contendo múltiplos organoides |
| Beneficiário: | Iris Renata Sousa Ribeiro |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |