| Texto completo | |
| Autor(es): |
Vien, Thuy N.
;
Ta, My C.
;
Kimura, Louise F.
;
Onay, Tuncer
;
DeCaen, Paul G.
Número total de Autores: 5
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA; v. 120, n. 22, p. 9-pg., 2023-05-30. |
| Resumo | |
Polycystins (PKD2, PKD2L1, and PKD2L2) are members of the transient receptor potential family, which form ciliary ion channels. Most notably, PKD2 dysregulation in the kidney nephron cilia is associated with polycystic kidney disease, but the function of PKD2L1 in neurons is undefined. In this report, we develop animal models to track the expression and subcellular localization of PKD2L1 in the brain. We discover that PKD2L1 localizes and functions as a Ca2+ channel in the primary cilia of hippocampal neurons that apically radiate from the soma. Loss of PKD2L1 expression ablates primary ciliary maturation and attenuates neuronal high-frequency excitability, which precipitates seizure susceptibility and autism spectrum disorder- like behavior in mice. The disproportionate impairment of interneuron excitability suggests that circuit disinhibition underlies the neurophenotypic features of these mice. Our results identify PKD2L1 channels as regulators of hippocampal excitability and the neuronal primary cilia as organelle mediators of brain electrical signaling. (AU) | |
| Processo FAPESP: | 19/26414-2 - Caracterização eletrofisiológica das correntes iônicas do cílio primário dos neurônios dos gânglios da raiz dorsal após estimulação inflamatória e sua modulação pela crotalfina |
| Beneficiário: | Louise Faggionato Kimura Vieira |
| Modalidade de apoio: | Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado |