| Texto completo | |
| Autor(es): |
Ribeiro, Victor Pena
;
Aldana-Mejia, Jennyfer Andrea
;
Arruda, Caroline
;
Candido, Ana Carolina Bolela Bovo
;
Magalhaes, Lizandra Guidi
;
Oliveira, Nicoli Dias
;
Veneziani, Rodrigo Cassio Sola
;
Bastos, Jairo Kenupp
;
Ambrosio, Sergio Ricardo
Número total de Autores: 9
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BIOMEDICAL CHROMATOGRAPHY; v. 37, n. 8, p. 11-pg., 2023-04-18. |
| Resumo | |
Propolis is a natural product of great economic and pharmacological importance. The flora surrounding the bee communities is a determining factor in the composition of propolis and therefore in its biological and medicinal properties. Brown propolis is one of the most important types of propolis in Brazil, produced in the southeastern region. The ethanolic extract of a brown propolis sample from Minas Gerais state was chemically characterized for the subsequent development of a RP-HPLC method, validated according to the standards of regulatory agencies. The leishmanicidal activity of this extract was assessed. The brown propolis was characterized by the presence of chemical markers reported on green propolis such as ferulic acid, coumaric acid, caffeic acid, cinnamic acid, baccharin, artepillin and drupanin, indicating a probable origin on Baccharis dracunculifolia. The developed method agreed with the parameters established by the validation guidelines, then proved to be reliable for the analysis of this type of propolis. The brown propolis displayed significant activity against Leishmania amazonensis with IC50 values of 1.8 and 2.4 mu g/ml against the promastigote and amastigote forms, respectively. The studied propolis exhibited promising evidence for use as a natural source against L. amazonensis. (AU) | |
| Processo FAPESP: | 22/00659-1 - Avaliação in vitro do metabolismo dos compostos majoritários da própolis marrom de Araucaria sp |
| Beneficiário: | Victor Pena Ribeiro |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 17/04138-8 - Realização de estudos químicos, analíticos, biológicos, farmacológicos e tecnológicos para preenchimento das lacunas no desenvolvimento do setor de própolis brasileiro |
| Beneficiário: | Jairo Kenupp Bastos |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |