Antimicrobial metabolites produced by endophytic fungi associated with the leaves of Vochysia divergens

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Souza, Jessica A. de M. ; Gubiani, Juliana R. ; de Siqueira, Katia A. ; de Camargo, Maria J. ; Garcez, Walmir S. ; de Sousa, Paulo T. ; Soares, Marcos A. ; Araujo, Angela R. ; Nunes, Emanuel V. dos S. ; Vieira, Lucas C. C. ; Sampaio, Olivia M. ; Goulart, Leticia S. ; Biasetto, Carolina R. ; de Menezes, Orivaldo T. ; de Oliveira, Camila M. ; Nogueira, Claudio R. ; Pinto, Luciano da S. ; Teles, Helder L.

• Tipo de documento: Artigo Científico
• Fonte: NATURAL PRODUCT RESEARCH; v. N/A, p. 8-pg., 2023-04-29.

Resumo

Investigation of the endophytic fungi Nigrospora sphaerica, Nigrospora oryzae, and Pseudofusicoccum stromaticum MeOH fractions isolated from the leaves of Vochysia divergens, a medicinal species from the Brazilian Pantanal, led to the identification of five compounds, namely a new compound (1E,8Z)-10,11-dihydroxy-5,5,8-trimethyl-4-oxocycloundeca-1,8-diene-1-carbaldehyde (1) and four known compounds: 5-methylmellein (2), sclerone (3), daldinone A (4), and lasiodiplodin (5). All compounds were identified using spectroscopic methods, and 1 was corroborated with mass spectrometry, while the known compounds were compared with data in the literature. The relative configuration of compound 1 was determined based on theoretical conformational studies as well as the J experimental values between the hydroxymethyne hydrogens. The antimicrobial activity of the compounds was evaluated. Promising results were obtained for compounds 2, 4, and 5 since they inhibited the bacterium Pseudomonas aeruginosa, an opportunistic pathogen, suggesting the potential of these microorganisms as a source of new antibacterial agents. (AU)

• Processo FAPESP: 17/06014-4 - Novos metabólitos secundários de organismos endofíticos e marinhos inibidores do proteassomo: um alvo validado contra câncer
• Beneficiário: Juliana Regina Gubiani
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 14/50926-0 - INCT 2014: biodiversidade e produtos naturais
• Beneficiário: Vanderlan da Silva Bolzani
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático