Advances in nano-based materials for glioblastoma multiforme diagnosis: A mini-review

Autor(es)

Gusmao, Luiza Araujo ; Matsuo, Flavia Sayuri ; Barbosa, Hellen Franciane Goncalves ; Tedesco, Antonio Claudio

• Tipo de documento: Artigo Científico
• Fonte: FRONTIERS IN NANOTECHNOLOGY; v. 4, p. 14-pg., 2022-08-31.

Resumo

The development of nano-based materials for diagnosis enables a more precise prognosis and results. Inorganic, organic, or hybrid nanoparticles using nanomaterials, such as quantum dots, extracellular vesicle systems, and others, with different molecular compositions, have been extensively explored as a better strategy to overcome the blood-brain barrier and target brain tissue and tumors. Glioblastoma multiforme (GBM) is the most common and aggressive primary tumor of the central nervous system, with a short, established prognosis. The delay in early detection is considered a key challenge in designing a precise and efficient treatment with the most encouraging prognosis. Therefore, the present mini-review focuses on discussing distinct strategies presented recently in the literature regarding nanostructures' use, design, and application for GBM diagnosis. (AU)

• Processo FAPESP: 13/50181-1 - Utilização de nanocarreadores contendo fármacos fotossensibilizantes e outros ativos aplicados à terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Antonio Claudio Tedesco
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 18/17911-0 - Nanocarreador lipídico revestido com polímero aplicado na veiculação de agentes terapêuticos para o diagnóstico e o tratamento de patologias do sistema nervoso central via administração intranasal
• Beneficiário: Hellen Franciane Gonçalves Barbosa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado