| Texto completo | |
| Autor(es): |
Reis, Fernando M. C. V.
;
Mobbs, Dean
;
Canteras, Newton S.
;
Adhikari, Avishek
Número total de Autores: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Neuropharmacology; v. 228, p. 11-pg., 2023-02-14. |
| Resumo | |
The midbrain periaqueductal gray (PAG) has been recognized for decades as having a central role in the control of a wide variety of defensive responses. Initial discoveries relied primarily on lesions, electrical stimulation and pharmacology. Recent developments in neural activity imaging and in methods to control activity with anatomical and genetic specificity have revealed additional streams of data informing our understanding of PAG function. Here, we discuss both classic and modern studies reporting on how PAG-centered circuits influence innate as well as learned defensive actions in rodents and humans. Though early discoveries emphasized the PAG's role in rapid induction of innate defensive actions, emerging new data indicate a prominent role for the PAG in more complex processes, including representing behavioral states and influencing fear learning and memory. (AU) | |
| Processo FAPESP: | 14/05432-9 - Bases neurais do medo e agressão |
| Beneficiário: | Newton Sabino Canteras |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |