Effect of experimental toothpaste containing hydroxyapatite nanoparticles and propolis, with and without fluoride, on the microcosm biofilm and enamel demineralization

Autor(es)

Ribeiro, Caroline Fernanda da Silva ; Dionizio, Aline ; Araujo, Tamara Teodoro ; Rodrigues, Chelsea Maria Vilas Boas Feitosa ; Mattos, Amanda Costa ; Otaviano, Leticia Galli ; Grizzo, Larissa Tercilia ; Magalhaes, Ana Carolina ; Buzalaf, Marilia Afonso Rabelo

• Tipo de documento: Artigo Científico
• Fonte: BIOFOULING; v. 39, n. 3, p. 10-pg., 2023-05-26.

Resumo

This study evaluated the antimicrobial and anticaries effects of toothpaste containing hydroxyapatite nanoparticles (nanoHAP - 5 or 10%), xylitol (2 or 3%) and propolis (1 or 2%), associated or not with 1500 ppm fluoride (F). An in vitro model was used with microcosm biofilm produced from a pool of human saliva and McBain saliva (1:50) in the first 8 h of culture on 162 bovine enamel specimens. At the end of the experimental period, analyses of metabolic activity, colony forming units (CFU) and transverse microradiography (TMR) were performed. This study showed a possible decrease in demineralization and increase in remineralization by the commercial toothpaste (1500 ppm F) and for the experimental toothpaste containing the highest concentration of all agents, combined with F. In addition, a reduction in antimicrobial activity possibly caused by propolis and xylitol, mainly in relation to cariogenic bacteria, was observed. (AU)

• Processo FAPESP: 19/03866-5 - Avaliação da eficiência de dentifrícios experimentais com nanopartículas de hidroxiapatita com ou sem fluoreto, na prevenção da cárie dentária
• Beneficiário: Caroline Fernanda da Silva Ribeiro
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica