Mathematical modeling for drug delivery and inflammation process: An application in macular edema

Autor(es)

Goncalves, M. B. ; Gudino, E. ; Maia, M. ; Oishi, C. M.

• Tipo de documento: Artigo Científico
• Fonte: Applied Mathematical Modelling; v. 121, p. 22-pg., 2023-05-27.

Resumo

In this paper, we introduce a mathematical model for the drug release from an intravitreal implant and the subsequent effect of the drug on the inflammation process of macular edema. Coupling the drug transport problem with the growth of the edema, we compare the numerical simulations with patient-specific medical images. We fit the model with respect to one parameter and match the retinal thickness observed in the patient. After the validation of the proposed model, we perform numerical experiments regarding patient-specific treatments. In particular, we analyze the drug concentration in the different sub-domains (e.g., the implant and the retina) and simulate the scenario of edema recurrence and implant re-injection. The proposed mathematical model has the potential to provide important insights into the use of intravitreal dexamethasone implants and the treatment of macular edema. & COPY; 2023 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/07375-0 - CeMEAI - Centro de Ciências Matemáticas Aplicadas à Indústria
• Beneficiário: Francisco Louzada Neto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs
• Processo FAPESP: 21/13833-7 - Métodos orientados por dados e aprendizado de máquina em mecânica dos fluidos não-Newtonianos
• Beneficiário: Cassio Machiaveli Oishi
• Modalidade de apoio: Bolsas no Exterior - Pesquisa