Retrospective Spatio-Temporal Dynamics of Dengue Virus 1, 2 and 4 in Paraguay

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Vazquez, Cynthia ; Alcantara, Luiz Carlos Junior ; Fonseca, Vagner ; Lima, Mauricio ; Xavier, Joilson ; Adelino, Talita ; Fritsch, Hegger ; Castro, Emerson ; de Oliveira, Carla ; Schuab, Gabriel ; Lima, Alex Ranieri Jeronimo ; Villalba, Shirley ; de la Fuente, Andrea Gomez ; Rojas, Analia ; Cantero, Cesar ; Fleitas, Fatima ; Aquino, Carolina ; Ojeda, Andrea ; Sequera, Guillermo ; Torales, Juan ; Barrios, Julio ; Elias, Maria Carolina ; Iani, Felipe C. M. ; Ortega, Maria Jose ; Gamarra, Maria Liz ; Montoya, Romeo ; Rodrigues, Evandra Strazza ; Kashima, Simone ; Sampaio, Sandra Coccuzzo ; Coluchi, Norma ; Leite, Juliana ; Gresh, Lionel ; Franco, Leticia ; Lourenco, Jose ; Rico, Jairo Mendez ; de Filippis, Ana Maria Bispo ; Giovanetti, Marta

• Tipo de documento: Artigo Científico
• Fonte: Viruses-Basel; v. 15, n. 6, p. 14-pg., 2023-06-01.

Resumo

Dengue virus (DENV) has been a major public health concern in Paraguay, with frequent outbreaks occurring since early 1988. Although control measures have been implemented, dengue remains a significant health threat in the country, and continued efforts are required for prevention and control. In response to that, in collaboration with the Central Public Health Laboratory in Asuncion, we conducted a portable whole-genome sequencing and phylodynamic analysis to investigate DENV viral strains circulating in Paraguay over the past epidemics. Our genomic surveillance activities revealed the co-circulation of multiple DENV serotypes: DENV-1 genotype V, the emerging DENV-2 genotype III, BR4-L2 clade, and DENV-4 genotype II. Results additionally highlight the possible role of Brazil as a source for the international dispersion of different viral strains to other countries in the Americas emphasizing the need for increased surveillance across the borders, for the early detection and response to outbreaks. This, in turn, emphasizes the critical role of genomic surveillance in monitoring and understanding arbovirus transmission and persistence locally and over long distances. (AU)

• Processo FAPESP: 21/11944-6 - Contínuo aprimoramento de vacinas: Centro para Vigilância Viral e Avaliação Sorológica (CeVIVAS)
• Beneficiário: Sandra Coccuzzo Sampaio Vessoni
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Ciência para o Desenvolvimento