Consequences of oxygen deprivation on myelination and sex-dependent alterations

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Fabres, Rafael Bandeira ; Cardoso, Debora Sterzeck ; Aragon, Brian Aranibar ; Arruda, Bruna Petrucelli ; Martins, Pamela Pinheiro ; Ikebara, Juliane Midori ; Drobyshevsky, Alexander ; Kihara, Alexandre Hiroaki ; de Fraga, Luciano Sturmer ; Netto, Carlos Alexandre ; Takada, Silvia Honda

• Tipo de documento: Artigo Científico
• Fonte: Molecular and Cellular Neuroscience; v. 126, p. 11-pg., 2023-06-03.

Resumo

Oxygen deprivation is one of the main causes of morbidity and mortality in newborns, occurring with a higher prevalence in preterm infants, reaching 20 % to 50 % mortality in newborns in the perinatal period. When they survive, 25 % exhibit neuropsychological pathologies, such as learning difficulties, epilepsy, and cerebral palsy. White matter injury is one of the main features found in oxygen deprivation injury, which can lead to long-term functional impairments, including cognitive delay and motor deficits. The myelin sheath accounts for much of the white matter in the brain by surrounding axons and enabling the efficient conduction of action potentials. Mature oligodendrocytes, which synthesize and maintain myelination, also comprise a significant proportion of the brain's white matter. In recent years, oligodendrocytes and the myelination process have become potential therapeutic targets to minimize the effects of oxygen deprivation on the central nervous system. Moreover, evidence indicate that neuroinflammation and apoptotic pathways activated during oxygen deprivation may be influenced by sexual dimorphism. To summarize the most recent research about the impact of sexual dimorphism on the neuroinflammatory state and white matter injury after oxygen deprivation, this review presents an overview of the oligodendrocyte lineage development and myelination, the impact of oxygen deprivation and neuroinflammation on oligodendrocytes in neurodevelopmental disorders, and recent reports about sexual dimorphism regarding the neuroinflammation and white matter injury after neonatal oxygen deprivation. (AU)

• Processo FAPESP: 20/16268-6 - Impacto da neuroinflamação e da participação do eixo intestino-cérebro na mielinização em modelo de anóxia neonatal em roedores combinado à inflamação perinatal por ativação imune materna
• Beneficiário: Silvia Honda Takada
• Modalidade de apoio: Auxílio à Pesquisa - Regular