Hybrid lipid-biopolymer nanocarrier as a strategy for GBM photodynamic therapy (PDT)

Autor(es)

Barbosa, Hellen Franciane Goncalves ; Piva, Henrique Luis ; Matsuo, Flavia Sayuri ; de Lima, Sarah Caroline Gomes ; de Souza, Lucas Eduardo Botelho ; Osako, Mariana Kiomy ; Tedesco, Antonio Claudio

• Tipo de documento: Artigo Científico
• Fonte: International Journal of Biological Macromolecules; v. 242, p. 14-pg., 2023-05-08.

Resumo

Glioblastoma (GBM) is the most common brain cancer characterized by aggressive and infiltrated tumors. For this, hybrid biopolymer-lipid nanoparticles coated with biopolymers such as chitosan and lipidic nanocarriers (LN) loaded with a photosensitizer (AlClPc) can be used for GBM photodynamic therapy. The chitosan-coated LN exhibited stable physicochemical characteristics and presented as an excellent lipid nanocarrier with highly efficiently encapsulated photosensitizer chloro-aluminum phthalocyanine (AlClPc). LN(AlClPc)Ct0.1% in the presence of light produced more reactive oxygen species and reduced brain tumor cell viability and proliferation. Confirm the effects of in vivo LN applications with photodynamic therapy confirmed that the total brain tumor area decreased without systemic toxicity in mice. These results suggest a promising strategy for future clinical applications to improve brain cancer treatment. (AU)

• Processo FAPESP: 18/17911-0 - Nanocarreador lipídico revestido com polímero aplicado na veiculação de agentes terapêuticos para o diagnóstico e o tratamento de patologias do sistema nervoso central via administração intranasal
• Beneficiário: Hellen Franciane Gonçalves Barbosa
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/50181-1 - Utilização de nanocarreadores contendo fármacos fotossensibilizantes e outros ativos aplicados à terapia celular e tratamento de patologias do sistema nervoso central
• Beneficiário: Antonio Claudio Tedesco
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 20/04009-6 - Desenvolvimento de biotinta para impressão em 3D de scaffolds para regeneração de estruturas cartilaginosas
• Beneficiário: Henrique Luis Piva
• Modalidade de apoio: Bolsas no Brasil - Doutorado Direto