| Texto completo | |
| Autor(es): |
Duarte, Josiane O.
;
Planeta, Cleopatra S.
;
Crestani, Carlos C.
Número total de Autores: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Life Sciences; v. 318, p. 11-pg., 2023-02-15. |
| Resumo | |
Aims: This study investigated the influence of exposure to stress during adolescence in autonomic, cardiovas-cular, neuroendocrine and somatic changes evoked by chronic stress in adult rats.Main methods: Animals were subjected to a 10-days protocol of repeated restraint stress (RRS, habituating) or chronic variable stress (CVS, non-habituating) during adolescence, adulthood, or repeated exposure to either RRS or CVS in adolescence and adulthood (adolescence+adulthood group). The trials to measure autonomic, car-diovascular, neuroendocrine and somatic changes in all experimental groups were performed in adulthood.Key findings: CVS increased basal circulating corticosterone levels and caused adrenal hypertrophy in the ado-lescence+adulthood group, an effect not identified in animals subjected to this stressor only in adulthood or adolescence. CVS also caused a sympathetically-mediated resting tachycardia in the adulthood group. This effect of CVS was not identified in the adolescence+adulthood group once the increased cardiac sympathetic activity was buffered by a decrease in intrinsic heart rate in these animals. Moreover, the impairment in baroreflex function observed in the adulthood group subjected to CVS was shifted to an improvement in animals subjected to repeated exposure to this stressor during adolescence and adulthood. The RRS in the adolescence+adulthood group caused a sympathetically-mediated resting tachycardia, which was not observed in the adulthood group.Significance: Our findings suggest that enduring effects of adverse events during adolescence included a vulnerability to neuroendocrine changes and a resilience to autonomic and cardiovascular dysfunctions caused by the CVS. Furthermore, results of RRS indicated a vulnerability to cardiovascular and autonomic changes evoked by homotypic stressors. (AU) | |
| Processo FAPESP: | 12/14376-0 - Comparação do efeito de dois protocolos de estresse crônico sobre a função cardiovascular e autonômica em ratos |
| Beneficiário: | Carlos Cesar Crestani |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 12/50549-6 - Envolvimento da neurotransmissão colinérgica no núcleo leito da estria terminal nas respostas autonômicas, neuroendócrinas e comportamentais desencadeadas pelo estresse por restrição agudo em ratos |
| Beneficiário: | Carlos Cesar Crestani |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 15/05922-9 - Estudo da participação da neurotransmissão CRFérgica do núcleo leito da estria terminal nas alterações cardiovasculares induzidas pelo estresse: interação com a via de sinalização receptor NMDA / óxido nítrico/guanilato ciclase / proteína quinase g? |
| Beneficiário: | Carlos Cesar Crestani |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 19/24478-3 - Estudo da participação do córtex insular no controle das respostas cardiovasculares e ansiogênica ao estresse em ratos: avaliação da topografia funcional e do envolvimento da neurotransmissão do fator de liberação de corticotrofina (CRF) |
| Beneficiário: | Carlos Cesar Crestani |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |