| Texto completo | |
| Autor(es): |
Goulart, Ssia da Luz
;
Caruso, Flavia Rossi
;
de Araujo, Adriana S. Garcia
;
Cristina Garcia de Moura, Silvia
;
Catai, Aparecida Maria
;
Batista dos Santos, Polliana
;
Kabbach, Erika Z.
;
Arena, Ross
;
Mendes, Renata Goncalves
;
Borghi-Silva, Audrey
Número total de Autores: 10
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Respiratory Care; v. 68, n. 3, p. 10-pg., 2023-03-01. |
| Resumo | |
BACKGROUND: We sought to assess whether noninvasive ventilation (NIV) as an adjunct with high-intensity exercise (HIEx) is more effective than exercise alone or exercise + sham on respi-ratory and peripheral oxygenation and vascular function in subjects with coexisting COPD and heart failure (HF). METHODS: On separate days, subjects performed incremental cardiopulmo-nary exercise testing and 3 constant load tests: HIEx, HIEx+NIV, and HIEx+sham (bi-level mode, Astral 150). Subjects were randomized with a 1:1 block allocation for the HIEx+NIV group and HIEx+sham group until the limit of tolerance (Tlim). Peripheral and respiratory oxy-genation were assessed by oxyhemoglobin (O2Hb) and deoxyhemoglobin (Hb) using near -infra-red spectroscopy in the respiratory and peripheral musculature. Vascular function was assessed by endothelial function using the flow-mediated vasodilation (FMD) method. RESULTS: There was a significant increase in FMD (mm), FMD (%), and shear stress in the HIEx+NIV group when compared to HIEx or HIEx+sham (P < .05). Less extraction of O2 (Hb) in the peripheral and respiratory muscles was observed in the HIEx+NIV group (P < .05). We also found correla-tions between peripheral muscle oxygenation (O2Hb) at the moment 80% of Tlim (r = 0.71, P = .009) and peak of Tlim (100%) (r = 0.76, P = .004) with absolute FMD (mm) immediately after HIEx+NIV. CONCLUSIONS: NIV as an adjunct to HIEx can acutely unload the respiratory musculature with better redistribution of available blood flow and beneficially modulate endo-thelial function. These results may influence the approach to cardiopulmonary rehabilitation inpatients with coexisting COPD-HF. (AU) | |
| Processo FAPESP: | 18/03233-0 - Estudo da interação cardiorrespiratória e da oferta de oxigênio periférica e cerebral como moduladores da capacidade de exercício durante a aplicação do binível na coexistência da DPOC-ICC |
| Beneficiário: | Cássia da Luz Goulart |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado Direto |