| Texto completo | |
| Autor(es): Mostrar menos - |
Braga Filho, Carlos Eduardo
;
Pereira Barbosa, Adriano Henrique
;
Duarte Nicolau, Lucas Antonio
;
Rolim Medeiros, Jand Venes
;
Pires-Oliveira, Marcelo
;
dos Santos Povoa, Rui Manuel
;
Penaranda Govato, Tania Carmen
;
Fernandes Fernandes Junior, Hezio Jadir
;
de Carvalho, Rafael Guzella
;
Luna-Filho, Braulio
;
Sabia Tallo, Fernando
;
de Araujo, Erisvaldo Amarante
;
Padrao Tavares, Jose Gustavo
;
Arida, Ricardo Mario
;
Caricati-Neto, Afonso
;
Menezes-Rodrigues, Francisco Sandro
Número total de Autores: 16
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE; v. 10, n. 3, p. 13-pg., 2023-03-01. |
| Resumo | |
Background: Although several studies suggest that heparins prevent arrhythmias caused by acute myocardial infarction (AMI), the molecular mechanisms involved remain unclear. To investigate the involvement of pharmacological modulation of adenosine (ADO) signaling in cardiac cells by a low-molecular weight heparin (enoxaparin; ENOX) used in AMI therapy, the effects of ENOX on the incidences of ventricular arrhythmias (VA), atrioventricular block (AVB), and lethality (LET) induced by cardiac ischemia and reperfusion (CIR) were evaluated, with or without ADO signaling blockers. Methods: To induce CIR, adult male Wistar rats were anesthetized and subjected to CIR. Electrocardiogram (ECG) analysis was used to evaluate CIR-induced VA, AVB, and LET incidence, after treatment with ENOX. ENOX effects were evaluated in the absence or presence of an ADO A1-receptor antagonist (DPCPX) and/or an inhibitor of ABC transporter-mediated cAMP efflux (probenecid, PROB). Results: VA incidence was similar between ENOX-treated (66%) and control rats (83%), but AVB (from 83% to 33%) and LET (from 75% to 25%) incidences were significantly lower in rats treated with ENOX. These cardioprotective effects were blocked by either PROB or DPCPX. Conclusion: These results indicate that ENOX was effective in preventing severe and lethal arrhythmias induced by CIR due to pharmacological modulation of ADO signaling in cardiac cells, suggesting that this cardioprotective strategy could be promising in AMI therapy. (AU) | |
| Processo FAPESP: | 17/25565-1 - Nova abordagem terapêutica da doença de Parkinson: Neuroproteção estimulada pela modulação farmacológica da sinalização intracelular pelo Ca2+/AMPc/NO |
| Beneficiário: | Afonso Caricati Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |